Opening of the Alfried Krupp Wissenschaftskolleg lecture series „Life Sciences“ to the topic „Post-translational modifications" by Prof. Elke Krüger and Prof. Michael Lammers:
"Protein lysine ubiquitination and acetylation as important post-translational modifications in cellular physiology, infection and disease“
Date: 24th April 2023
Time: 6 p.m.
Location: Alfried Krupp Wissenschaftskolleg Greifswald
The control of cellular processes by gene expression is well established, however regulation can be also achieved by myriads of modular post-translational modification (PTM) cascades. Typically, PTMs are enzymatically attached to specific proteinogenic amino acids to extend their chemical repertoire by modifying an existing functional group or introducing a new one. “Writers”, which catalyze PTMs, and “readers”, which recognize them, collaboratively transduce input signals into specific cellular outputs. “Erasers” counteract these processes by removing the PTMs. We concentrate here on lysine ubiquitination and acetylation as important PTM in cellular physiology, infection and disease.