Vortragsreihe des Alfried Krupp Wissenschaftkollegs "Life Science": "Unconventional ubiquitin code in infection and inflammation" von Professor Dr. Ivan Dikic/Goethe University Frankfurt

Alfried Krupp Kolleg lecture series „Life Sciences“: Lecture by Professor Dr. Ivan Dikic/Goethe University Frankfurt


Title:   Unconventional ubiquitin code in infection and inflammation


Date: 5th June 2023
Time: 6 p.m.
Location: Alfried Krupp Wissenschaftskolleg Greifswald


Ubiquitination of proteins regulates a number of key cellular proces­ses including protein degradation, endocytosis, translation, innate immunity and DNA repair. The major progress has been accomplis­hed in linking diverse Ubiquitin modifications (Ub code) with spe­cific cellular functions. These include conventional (lysine-linked) and unconventional ubiquitin modifications – from ester linkages to hydroxyls on proteins, lipids, sugars, to linkage via a ubiquitin seri­ne residue in phosphoribosyl-linked (PR) ubiquitination mediated by effector proteins of pathogenic Legionella pneumophila. Molecular insights into this novel chemistry of ubiquitination that can modula­te host-pathogen interactions, inflammation and immune responses during bacterial infection will be discussed.


Ivan Đikić is a leading expert in the fields of ubiquitin biology and autophagy research. He is Professor and Director of the Institute of Biochemistry II at Goe­the University Frankfurt and a fellow of Max Planck Society. He investigates molecular principles of life and their pathological alterations that lead to the development of human diseases such as cancer, neurodegeneration and infec­tion. For his scientific work he received numerous awards, including the Louis-Jeantet Prize, Jung Prize for Medicine and the Leibniz Prize.

Moderation: Professor Dr. Elke Krüger

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