Norman's paper on Improved Adsorption of the Antimicrobial Agent Poly (Hexamethylene) Biguanide on Ti-Al-V Alloys by NaOH Treatment and Impact of Mass Coverage and Contamination on Cytocompatibility is published

Graphical abstract figure
Figure 4. A. Snapshots near the end of water contact angle simulations on TiO2 slabs with increasing pentanol coverage. The percentages of 25%, 50%, 75% and 100%, denote the coverage remaining, after randomly removing pentanol molecules from the simulated equilibrium coverage and this assigns to 0.99, 1.98, 2.97 and 3.96 pentanol molecules per nm2 , respectively. The titanium dioxide crystal is represented by smaller atoms (O: red; Ti: pink). Hydroxylation groups and sodium ions on the top and bottom interfaces are drawn as bigger atoms (O: orange; H: white; Na+: magenta). The pentanol molecules (C: grey; O: red) sit on top of the TiO2 surface with their OH− group pointing downwards. The water droplet on top (O: cyan), builds different contact angles with the slab and this depends strongly on the hydrocarbon contamination level. B. (left) Illustrative snapshot of WCA simulations on pure PHMB surfaces as excerpts of larger micelles with brush-like aggregation of polymer strands. The PHMB oligomers (C: grey; N: blue; Cl−: green) stand upright with the PHA and PHT end-groups at the bottom and top, respectively. To differentiate the end-groups visually from the main chain repeat PHM, the carbon atoms of PHA and PHT are colored in different purple shades. (right) Top view. C. Results from simulated WCA on pentanol-coated titanium dioxide slabs in comparison to experimentally derived contamination levels [39] and wetting properties obtained in vitro in our study. A linear regression y = 1.3156 − 0.35209x yields R^2 = 0.97.

Unlike the native surface of the implant material (Ti6Al4V), oxidation with H2O2 leads to increased binding of the effective antimicrobial agent poly(hexamethylene) biguanide [PHMB]. However, treating with NaOH instead results in an even higher PHMB mass coverage. After oxidation with H2O2, strong differences in the PHMB adsorption capability between polished and corundum-blasted surfaces appear, indicating a roughness dependence. After NaOH treatment, no such effect was observed. The wetting properties of specimens treated with either H2O2 or NaOH prior to PHMB exposure clearly varied. To unravel the nature of this interaction, widespread in silico and in vitro experiments were performed.

Norman's paper on Improved Adsorption of the Antimicrobial Agent Poly (Hexamethylene) Biguanide on Ti-Al-V Alloys by NaOH Treatment and Impact of Mass Coverage and Contamination on Cytocompatibility is published in Coatings. Congratulations Norman!

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