Una's paper on Reconstitution of Functional Integrin αIIbβ3 in Plasma Membrane-Mimetic Membranes is published
TEM negative stain images of Ld/Lo αIIbβ3 proteoliposomes and empty liposomes containing DOPC:SM:cholesterol (45:35:25 mol%) prepared with different reconstitution protocols. Proteoliposomes (top) and analogously prepared empty liposomes (bottom) were prepared using the (A,B) biobead protocol or (C,D) dialysis protocol. Densities corresponding to the characteristic αIIbβ3 extracellular domains are indicated by arrow heads.
Studying the platelet receptor integrin αIIbβ3 in a membrane-mimetic environment without interfering signalling pathways as a useful platform do dissect disease-relevant integrin mutations and effects on ligand binding in a lipid-specific context, applicable for drug screening...
Una's paper on Reconstitution of Functional Integrin αIIbβ3 and Its Activation in Plasma Membrane-Mimetic Lipid Environments is published in Membranes. Congratulations Una
