New publication in Nature Communications shows distribution and diversity of classical deacylases in bacteria.

Classical Zn2+-dependent deac(et)ylases play fundamental regulatory roles in life. In bacteria, however, classical deacylases are less well understood. We identify thousands of uncharacterized classical deacylases in bacteria, which are grouped into five clusters and performed systematic structural and functional characterization of representative enzymes. We define the structural requirements of substrate selectivity, and discovered bacterial de-D-/L-lactylases and long-chain deacylases. Bacterial deacylases are inhibited by archetypal HDAC inhibitors setting the ground for drug repurposing strategies to fight bacterial infections.

Publication:
Link: https://rdcu.be/dYZb6