Das Institut für Biochemie lädt gemeinsam mit dem Ortsverband der Gesellschaft Deutscher Chemiker zu einem
K o l l o q u i u m der GDCh
Großer Hörsaal des Instituts für Biochemie
Felix-Hausdorff-Str. 4, Greifswald
Montag, 07. Juli 2025, 16 Uhr c.t.
Prof. Dr. Elmar Behrmann
Universität zu Köln, Institute of Biochemistry
spricht zum Thema:
One is the Loneliest Number - the power of CryoEM to reveal unexpected oligomeric assemblies
Abstract: Artificial intelligence, or more precisely machine learning, is not only revolutionising our daily lives, it has also become an essential tool for science. In structural biology, deep learning tools such as Alphafold2 or RoseTTAFold promise to provide protein structures at the click of a button. However, because these tools are based on extrapolating information from existing knowledge, they tend to underestimate the creativity of evolution in finding new applications for existing protein folds. Cryo-electron microscopy, on the other hand, as an image-based method, allows proteins to be visualised at near-atomic resolution without requiring prior assumptions about protein structure, and is therefore ideally suited to reveal such new applications for existing folds. In my talk, I will use three recent examples from our lab - a light-sensitive protein that helps marine worms sense the phase of the moon, a synaptic scaffolding protein that helps our brain balance its activity, and an immunoreceptor protein that helps a plant defend itself against pathogenic fungi - to highlight the power of cryo-EM to reveal unexpected oligomeric assemblies and resolve them to near-atomic resolution, thereby improving our functional and mechanistic understanding of these proteins.
Einladender Prof. Dr. Michael Lammers
Dr. Christian Fischer
Vorsitzender des Ortsverbandes der GDCh