Lipid rafts are specialized domains in the cell membrane and are critical for many cell transduction mechanisms. Any modifications to lipid rafts can alter their functionality, especially in stress conditions. Although studies on the effect of cholesterol concentration and its oxidation on membrane characteristics have been known, understanding the influence of sphingomyelin is equally important. Here, we look into whether nitric oxide radical can perturb the membrane permeability and bilayer thickness with changing sphingomyelin and nitric oxide concentration.
Sanjai's paper on Identification of a critical lipid ratio in raft-like phases exposed to nitric oxide: An AFM study is published Biopysical Journal. Congratulations Sanjai