Publication in Nature Communications

In this publication in Nature Communications we report on our studies about proteases involved in acute pancreatitis. We have identified that cystatin C (CST3) acts as an endogenous inhibitor of two other key proteases (CTSB and CTSL) and identified that CST3 is a critical regulator of activity for both proteases during acute pancreatitis. Furthermore, we found that dimerised CST3 enhances the CTSB activity and shifts from an inhibitor to an activator of CTSB. Special thanks go to the entire team for the great collaboration within the DFG-funded research training group RTG-PRO. Enjoy reading our publication here.