Patents (open to the public)

[49] Feldman, A., Palluk, S., Arlow, D., Bertram, J.G., Raliski, B., Raines, R.T., Bornscheuer, U.T., Fessner, N.D., Badenhorst, C.P.S., (2022), Cleavable linkers for the tethering of polymerases to nucleotides, PCT Patent Application. WO/2024/073349.
[48] Reisky, L., Jäger, G., Söltl, S., Essmann, V., Pochorovski, I., Bornscheuer, U.T., Badenhorst, C.P.S., Buchmann, C., Branson, Y., Wei, R., (2022), Neue Urethanasen für den enzymatischen Abbau von Polyurethanen, PCT Patent Application, WO2023194440A1.
[47] Bornscheuer, U., Kim, I.J., Zorn, H., Geißler, T., Ley, J.P., Harms, C., Otte-Hölscher, S., Bruns, S., Fraatz, M.A., Hammer, A.K., Honold, P. (2023), Aldehyde mixtures for flavor improvement, PCT Patent Application, WO2023104293.
[46] Bornscheuer, U., Kim, I.J., Bayer, T., Brack, Y. (2023), Process for the enzymatic preparation of aldehydes, PCT Patent Application, WO2023030967.
[45] Geissler, T., Ley, J.P., Zirpel, B., Yi, D., Bornscheuer, U. (2022), Enzymatic production of dihydrochalcones using recombinant ene reductases and chalcone isomerase, PCT Patent Application, WO2022184248.
[44] Bornscheuer, U., Grobe, S., Hamnevik, E., Bayer, T., Badenhorst, C., Brundiek, H., Großjohann, B., (2022), Mutagenesis of Streptomyces antibioticus cytochrome P450 monooxygenase CYP107D1 for 7-beta-hydroxylation of bile acid derivatives, European Patent Application, EP3933036.
[43] Geißler, T., Ley, J.P., Backes, M., Harms, C., Bornscheuer, U.T., Balke, K., Zorn, H., Fraatz, M.A., Hammer, A.K. (2020), Biotechnological production of aldehyde mixtures by recombinant microorganisms, PCT Patent Application, WO2021180327.
[42] Bornscheuer, U., Hanlon, S.P., Iding, H., Pavlidis, I., Spurr, P., Weiss, M.S. Wirz, B. (2016) Mutant transaminases as well as methods and uses relating thereto, PCT Patent Application, WO2016/166120; US 2016/0304843.
[41] Thomsen, M., Bornscheuer U.T., Hinrichs, W., Gross, E., Ley, J., Geissler, T. Process for the biotechnological production of flavanonglycoside dihydrochalcones, European Patent Application EP2963109.
[40] Schmidt, S., Bornscheuer, U.T., Menyes, U., Wardenga, R., Borchert, S., Process for the production of polyesters using an enzyme cascade of alcohol dehydrogenase, cyclohexanone monooxygenase and lipase A. Patent Application, EP 2899280; WO 2015113848.
[39] Byström, E. Scherman, H., Bornscheuer, U., Irgum K., Immobilization of enzymes or cells on a rotating flow distributor for efficient chemical or biological transformation. PCT Patent Application, WO2915050491.
[38] Hilmer, J.M., Gross, E., Krammer G., Ley, J.P., Gall, M., Bornscheuer, U.T., Thomsen, M., Peters, C., Jonczyk, P., Beutel, S., Scheper, T., Method for the biotechnological manufacture of dihydrochalcones, Patent Application. EP 2692729, DE 102012213492.
[37] Bornscheuer, U., Brundiek, H., Evitt, A., Sass, S., Boenisch, F., Kourist, R. (2013), Polynucleotides, vectors, and host cells expressing improved lipase variants, US Patent Application, US 20130196411.
[36] Bornscheuer, U., Brundiek, H., Evitt, A., Sass, S., Boenisch, F., Kourist, R. (2013), Reduced-fat foodstuffs and cooking oils, and methods for making the same, US Patent Application, US 20130171321.
[35] Bornscheuer, U., Brundiek, H., Evitt, A., Sass, S., Boenisch, F., Kourist, R. (2012), Lipase variants, US Patent Application, US 20120276247.
[34] Bornscheuer, U., Brundiek, H., Evitt, A., Sass, S., Boenisch, F., Kourist, R. (2012), Lipase variants having increased enzyme specificity or enhanced trans-selectivity, and methods of use, PCT Patent Application, WO 2012146935.
[33] Bornscheuer, U., Brundiek, H., Evitt, A., Sass, S., Boenisch, F., Kourist, R. (2012), Lipase variants of ustilaginaceae, PCT Patent Application, WO 2012146937.
[32] Bornscheuer, U.T, Vorhaben, T., Böttcher, D., Jasinski, D., Menyes, U., Häckel, M., Schröder, K. (2011) Immobilisierung von Enzym unter Verwendung von Plasmen, PCT Patent Application WO 2011131594.
[31] Bornscheuer, U.T. Gerstenbruch, S., Mußmann, N., Maurer, K.-H., O'Connell, T. (2010) Mutanten einer Sorbitoloxidase mit verbesserter spezifischer Aktivität auf Glycerin, German Patent Application DE10 2010 028008.
[30] Bornscheuer, U., Hesseler, M. (2011), Method for the conversion of 3-halogen-1,2-propanediol and its mono- and diester derivatives to 1,2,3-propanetriol, Patent Applications DE 10 2009 042 760.0; WO 2011036072.
[29] Robins, K., Höhne, M., Bornscheuer, U.T. (2011), Screening, purification and characterization of microbial (R)-specific ω- transaminases and use for asymmetric synthesis of (R)-amines, PCT Patent Application WO 2011026556.
[28] Bornscheuer, U., Böttcher, D., Brüsehaber, E., Doderer, K. (2010), Recombinant production of pig liver esterase in E. coli using GroEL/GroES chaperone system, US Patent application.
[27] Bornscheuer, U.T., Hummel, A., Böttcher, D., Brüsehaber, E., Doderer, K., Trauthwein, H. (2008), New variants of pig liver esterase gamma for use in stereospecific hydrolysis. Intern. Patent PCT WO 2008116745; German Patent DE 102007014742.
[26] Robins, K., Bornscheuer, U., Höhne, M. (2008) Process for preparation of optically active n-protected 3 -aminopyrrolidine or optically active n-protected 3-aminopiperidine and the corresponding ketones by optical resolution of the racemic amine mixtures employing a bacterial omega-transaminase. Intern. Patent PCT WO 2008028654.
[25] Bornscheuer, U.T., Kirschner, A. (2008), Kinetic resolution of β-hydroxyketones by a cloned Baeyer-Villiger monooxygenase from Pseudomonas flourescens. Granted patent: DE 102006039189 B4 20100729; Intern. Patent PCT WO 2008022.
[24] Liebeton, K., Eck,. J., Bornscheuer, U.T., Böttcher, D., Langer, P., Bellur, E. (2007), A novel group of esterases for the enantioselective production of fine and specialty chemicals, Intern. Patent PCT WO 2007128496.
[23] Robins, K., Bornscheuer, U., Höhne, M. (2007), Process for the preparation of optically active chiral amines. European Patent EP 1818411.
[22] Jackisch, B.O., Simmler-Hübenthal, H., Zschau, W., Bornscheuer, U.T., Durban, M., Riemer, C. (2007), Use of a thermostable phospholipase in the degumming of an oil or fat, and a method for obtaining a thermostable phospholipase, European Patent EP 1788080.
[21] Bornscheuer, U.T., Schmidt, M., Kähler, M., Rieks, A. (2006), New esterases and their use for processes for kinetic resolution of butinolesters, Intern. Patent PCT WO 07/042444.
[20] Bornscheuer, U.T., Grüning, B., Hills, G., Möbius, P., Thum, O., Weitemeyer, C. (2005), Process for the enzymatic synthesis of ethers. German Patent DE102005043669, US Patent 2007059789.
[19] Bornscheuer, U.T., Weiner, D.P., Hitchman, T., Lyon, J., Wongsakul, S. (2005), Hydrolases, nucleic acids encoding them and mehods for making and using them. European Patent EP 1601332; International Patent PCT WO 05/032496.
[18] Bornscheuer, U.T., Musidlowska-Persson, A., Trauthwein, H. (2004), Artificial esterases. German Patent DE 10258327.
[17] Bornscheuer, U.T., Konarzycka, M., Hills, G. (2003). Assay for synthesis activity of hydrolases in nonaqueous media using enzymic transesterification reaction releasing a carbonyl compd. European Patent EP 1354960.
[16] Bornscheuer, U.T., Baumann, M. (2002), Detection method for identifying hydrolases. German Patent DE 101 24 799; European Patent EP 1395673; International Patent PCT WO 02/94949.
[15] Short, J., Mathur, E., Baumann, M., Bornscheuer, U. (2002), Hydrolase enzymes and their use in kinetic resolution. International Patent WO 02/057411.
[14] Tscherry, B., Bornscheuer, U., Musidlowska, A., Werlen, J. Zimmermann, T. (2002), Manufacture of L-carnitine from betaine esters with microorganisms bearing a betaine ester hydrolase. European Patent EP 1370663; International Patent PCT WO 02/061094; TW 316547 B 20091101.
[13] Riermeier, T., Bornscheuer, U., Altenbuchner, J., Hildebrandt, P. (2002), An alcohol dehydrogenase from Pseudomonas fluorescens for use in the manufacture of alcohols from ketones. German Patent DE 10112401; European Patent EP 1241263.
[12] Bornscheuer, U., Musidlowska, A., Schmidt-Dannert, C., Lange, S. (2002), Rekombinante Schweineleberesterase, deren Verwendung sowie ein Verfahren zu deren Herstellung. German Patent DE 10061864; European Patent EP 1343902; International Patent PCT WO 02/048322.
[11] Wessjohann L.A., Scheid G., Bornscheuer U., Henke E., Kuit W., Orru R. (2002), Epothilone synthesis components III and IV: Asymmetrically substituted acyloins and acyloin derivatives, method for the production thereof and method for the production of Epothilone B, D and Epothilone derivatives. German Patent DE 10134172 ; European Patent EP 1358144; US Patent US 6,867,333; International Patent PCT WO 02/32844.
[10] Bornscheuer, U.T., Meyer, H.H., Altenbuchner, J., (2002), Alteration of substrate specificity of enzymes, German Patent DE 19743683; European Patent EP 0909821; US Patent US 6,365,398.
[9] Gatfield, I., Hilmer, J.M., Bornscheuer, U., Schmid, R.D., Vorlova, S., (2002), Method for preparing D- and L-menthol. German Patent DE 10100913; European Patent EP 1223223; US Patent US 6,706,500.
[8] Brocca, S., Bornscheuer, U., Pleiss, J., Schmid, R.D., Schmid, U., Schmitt, J. Modified lypolytic enzymes and their use. European Patent EP 1130100.
[7] Bornscheuer, U., Henke, E., Yang, H. (2002), Verfahren zur Herstellung von stereoisomeren Carbonsäureestern, German Patent DE 19908074; European Patent EP 1031629; US Patent US 6,365,398.
[6] Yang,H., Henke, E., Bornscheuer, U.T. (2000), Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern. German Patent DE 19844876; European Patent EP 0997534; US Patent US 6,201,147.
[5] Bornscheuer, U.T, Schmid, R.D., Scheib, H., Otto, R.T., Syldatk, C. (2000), Method for the production of uronic acid esters in a lipase-catalyzed process. German Patent DE 19839219.
[4] Bornscheuer, U., Schmid, R.D., Syldatk, C., Youchun, Y., Otto, R. (2000), Verfahren zur selektiven Veresterung von Polyolen. German Patent DE 19924221.
[3] Otto, R., Syldatk, C., Cao, L., Bornscheuer, U., Schmid, R.D. (1999), Verfahren zur selektiven Veresterung von Polyolen. German Patent DE 19753789; European Patent EP 1175500.
[2] Bornscheuer, U.T., Soumanou, M.M., Schmid, R.D., Schmid, U. (1998), Preparation of symmetrical triglycerides ABA, European Patent EP 0882797.
[1] Minning, S., Bornscheuer, U., Schmid, R.D. (1998), Azo dye for detection of percarboxylic acids, German Patent DE 19651797.