[1] Zühlke MK, Schlüter R, Mikolasch A, Henning AK, Giersberg M, Lalk M, Kunze G, Schweder T, Urich T, Schauer F. (2020) Biotransformation of bisphenol A analogues by the biphenyl-degrading bacterium Cupriavidusbasilensis - a structure-biotransformation relationship. Appl Microbiol Biotechnol. 2020 Apr;104(8):3569-3583. doi: 10.1007/s00253-020-10406-4. Epub 2020 Mar 3.
[2] Schultz D, Surabhi S, Stelling N, Rothe M, Group KS, Methling K, Hammerschmidt S, Siemens N, Lalk M. (2020) 16HBE Cell Lipid Mediator Responses to Mono and Co-Infections with Respiratory Pathogens. Metabolites. 2020 Mar 18;10(3). pii: E113. doi: 10.3390/metabo10030113.
[3] Leonard A, Möhlis K, Schlüter R, Taylor E, Lalk M, Methling K. (2020) Exploring metabolic adaptation of Streptococcus pneumoniae to antibiotics. J Antibiot (Tokyo). 2020 Mar 24. doi: 10.1038/s41429-020-0296-3. [Epub ahead of print]
[4] Boonstra M, Schaffer M, Sousa J, Morawska L, Holsappel S, Hildebrandt P, Sappa PK, Rath H, de Jong A, Lalk M, Mäder U, Völker U, Kuipers OP. (2020) Analyses of competent and non-competent subpopulations of Bacillus subtilis reveal yhfW, yhxC and ncRNAs as novel players in competence. Environ Microbiol. 2020 Apr 5. doi: 10.1111/1462-2920.15005. [Epub ahead of print]
[1] Ashraf K, Yasrebi K, Adeniyi ET, Hertlein T, Ohlsen K, Lalk M, Erdmann F, Hilgeroth A. (2019) Antistaphylococcal evaluation of indole-naphthalene hybrid analogs. Drug Des Devel Ther. 2019 Jan 10;13:275-283. doi: 10.2147/DDDT.S184965
[2] Hilgeroth A, Yasrebi K, Suzen S, Hertlein T, Ohlsen K, Lalk M. (2019) Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains. Med Chem. 2019;15(8):833-839. doi: 10.2174/1573406415666190208170126.
[3] Graf AC, Leonard A, Schäuble M, Rieckmann LM, Hoyer J, Maass S, Lalk M, Becher D, Pané-Farré J, Riedel K. (2019) Virulence Factors Produced by Staphylococcus aureus Biofilms Have a Moonlighting Function Contributing to Biofilm Integrity. Mol Cell Proteomics. 2019 Jun;18(6):1036-1053. doi: 10.1074/mcp.RA118.001120. Epub 2019 Mar 8.
[4 Ponsuksili S, Trakooljul N, Hadlich F, Methling K, Lalk M, Murani E, Wimmers K. (2019) Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters. Front Genet. 2019 Apr 17;10:348. doi: 10.3389/fgene.2019.00348. eCollection 2019.
[5] Schultz D, Methling K; KoInfekt Study Group, Rothe M, Lalk M. (2019) Eicosanoid Profile of Influenza A Virus Infected Pigs. Metabolites. 2019 Jul 3;9(7). pii: E130. doi: 10.3390/metabo9070130.
[6] Kohler C, Proctor RA, Bayer AS, Yeaman MR, Lalk M, Engelmann S, Mishra NN. (2019) Proteomic and Membrane Lipid Correlates of Reduced Host Defense Peptide. Antibiotics (Basel). 2019 Sep 28;8(4). pii: E169. doi: 10.3390/antibiotics8040169.
[7] Sousa J, Westhoff P, Methling K, Lalk M. (2019) The Absence of Pyruvate Kinase Affects Glucose-Dependent Carbon Catabolite Repression in Bacillus subtilis. Metabolites. 2019 Oct 4;9(10). pii: E216. doi: 10.3390/metabo9100216.
[8] Seinen J, Dieperink W, Mekonnen SA, Lisotto P, Harmsen HJM, Hiemstra B, Ott A, Schultz D, Lalk M, Oswald S, Hammerschmidt S, de Smet AMGA, van Dijl JM. (2019) Heterogeneous antimicrobial activity in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients. Virulence. 2019 Dec;10(1):879-891. doi: 10.1080/21505594.2019.1682797.
[9] Seethaler M, Hertlein T, Wecklein B, Ymeraj A, Ohlsen K, Lalk M, Hilgeroth A. (2019) Novel Small-molecule Antibacterials against Gram-positive Pathogens of Staphylococcus and Enterococcus Species. Antibiotics (Basel). 2019 Nov 2;8(4). pii: E210. doi: 10.3390/antibiotics8040210.
[10] Siemens N, Oehmcke-Hecht S, Hoßmann J, Skorka SB, Nijhuis RHT, Ruppen C, Skrede S, Rohde M, Schultz D, Lalk M, Itzek A, Pieper DH, van den Bout CJ, Claas ECJ, Kuijper EJ, Mauritz R, Sendi P, Wunderink HF, Norrby-Teglund A. (2019) Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment. J Innate Immun. 2019 Nov 19:1-13. doi: 10.1159/000504002. [Epub ahead of print]
[1] Viana F, Paz LC, Methling K, Damgaard CF, Lalk M, Schramm A, Lund MB. (2018) Distinct effects of the nephridial symbionts Verminephrobacter and Candidatus Nephrothrix on reproduction and maturation of its earthworm host Eisenia andrei. FEMS Microbiol Ecol. 2018 Feb 1;94(2). doi: 10.1093/femsec/fix178.
[2] Leonard A, Gierok P, Methling K, Gómez-Mejia A, Hammerschmidt S, Lalk M. (2018) Metabolic inventory of Streptococcus pneumoniae growing in a chemical defined environment. Int J Med Microbiol. 2018 Jan 3. pii: S1438-4221(17)30487-3. doi: 10.1016/j.ijmm.2018.01.001.
[3] Leonard A, Lalk M. (2018) Infection and metabolism - Streptococcus pneumoniae metabolism facing the host environment. Cytokine. 2018 Dec;112:75-86. doi: 10.1016/j.cyto.2018.07.021
[4] Jarick M, Bertsche U, Stahl M, Schultz D, Methling K, Lalk M, Stigloher C, Steger M, Schlosser A, Ohlsen K. (2018) The serine/threonine kinase Stk and the phosphatase Stp regulate cell wall synthesis in Staphylococcus aureus. Sci Rep. 2018 Sep 12;8(1):13693. doi: 10.1038/s41598-018-32109-7
[5] Shaulov Y, Shimokawa C, Trebicz-Geffen M, Nagaraja S, Methling K, Lalk M, Weiss-Cerem L, Lamm AT, Hisaeda H, Ankri S. (2018) Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate. PLoS Pathog. 2018 Oct 11;14(10):e1007295. doi: 10.1371/journal.ppat.1007295
[6] Uifalean A, Rath H, Hammer E, Ionescu C, Iuga CA, Lalk M. (2018) Influence of soy isoflavones in breast cancer angiogenesis: a multiplex glass ELISA approach. J BUON. 2018 Dec;23(7):53-59
[1] Zwicker P, Schultze N, Niehs S, Albrecht D, Methling K, Wurster M, Wachlin G, Lalk M, Lindequist U, Haertel B. (2017) Differential effects of Helenalin, an anti-inflammatory sesquiterpene lactone, on the proteome, metabolome and the oxidative stress response in several immune cell types. Toxicol In Vitro. 2017 Apr;40:45-54. doi: 10.1016/j.tiv.2016.12.010.
[2] Zühlke MK, Schlüter R, Mikolasch A, Zühlke D, Giersberg M, Schindler H, Henning AK, Frenzel H, Hammer E, Lalk M, Bornscheuer UT, Riedel K, Kunze G, Schauer F. (2017) Biotransformation and reduction of estrogenicity of bisphenol A by the biphenyl-degrading Cupriavidus basilensis. Appl Microbiol Biotechnol. 2017 May;101(9):3743-3758. doi: 10.1007/s00253-016-8061-z.
[3] Dhali D, Coutte F, Arias AA, Auger S, Bidnenko V, Chataigné G, Lalk M, Niehren J, de Sousa J, Versari C, Jacques P. (2017) Genetic engineering of the branched fatty acid metabolic pathway of Bacillus subtilis for the overproduction of surfactin C14 isoform. Biotechnol J. 2017 Jul;12(7). doi: 10.1002/biot.201600574.
[4] Shahi P, Trebicz-Geffen M, Nagaraja S, Hertz R, Baumel-Alterzon S, Methling K, Lalk M, Mazumder M, Samudrala G, Ankri S. (2017) N-acetyl ornithine deacetylase is a moonlighting protein and is involved in the adaptation of Entamoeba histolytica to nitrosative stress. Sci Rep. 2017 Apr 5;7:45802. doi: 10.1038/srep45802.
[5] Ashraf K, Yasrebi K, Hertlein T, Ohlsen K, Lalk M, Hilgeroth A. (2017) Novel Effective Small-Molecule Antibacterials against Enterococcus Strains. Molecules. 2017 Dec 10;22(12). pii: E2193. doi: 10.3390/molecules22122193.
[6] Schultz D, Schlüter R, Gerth U, Lalk M. (2017) Metabolic Perturbations in a Bacillus subtilis clpP Mutant during Glucose Starvation. Metabolites 7(4), 63; doi: 10.3390/metabo7040063
[1] Uifalean, A., Schneider, S., Ionescu, C., Lalk, M., and Iuga, C. A. (2016) Soy Isoflavones and Breast Cancer Cell Lines: Molecular Mechanisms and Future Perspectives. Molecules21
[2] Shahi, P., Trebicz-Geffen, M., Nagaraja, S., Alterzon-Baumel, S., Hertz, R., Methling, K., Lalk, M., and Ankri, S. (2016) Proteomic Identification of Oxidized Proteins in Entamoeba histolytica by Resin-Assisted Capture: Insights into the Role of Arginase in Resistance to Oxidative Stress. PLoS neglected tropical diseases10
[3] Kumpfmueller, J., Methling, K., Fang, L., Pfeifer, B. A., Lalk, M., and Schweder, T. (2016) Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis. Applied Microbiology and Biotechnology100, 1209-1220
[4] Gierok, P., Kohler, C., Steinmetz, I., and Lalk, M. (2016) Burkholderia pseudomallei Colony Morphotypes Show a Synchronized Metabolic Pattern after Acute Infection. PLoS neglected tropical diseases10, e0004483-e0004483
[5] Alresly, Z., Lindequist, U., Lalk, M., Porzel, A., Arnold, N., and Wessjohann, L. A. (2016) Bioactive Triterpenes from the Fungus Piptoporus betulinus. Records of Natural Products10, 103-108
[6] Gierok P, Harms M, Methling K, Hochgräfe F, Lalk M. (2016) Staphylococcus aureus Infection Reduces Nutrition Uptake and Nucleotide Biosynthesis in a Human Airway Epithelial Cell Line. Metabolites 6(4) 41. doi: 10.3390/metabo6040041
[7] Zühlke D, Dörries K, Bernhardt J, Maas S, Muntel J, Liebscher V, Panne-Farre J, Riedel K, Lalk M, Völker U, Engelmann S, Becher D, Fuchs S, Hecker M. (2016) Costs of life - Dynamics of the protein inventory of Staphylococcus aureus during anaerobiosis. Sci Rep. 6, 28172, doi: 10.1038/srep28172
[1] Zwicker, P., Schultze, N., Niehs, S., Methling, K., Wurster, M., Bernhardt, J., Wachlin, G., Lalk, M., Preissner, R., Lindequist, U., and Haertel, B. (2015) Omics technologies for the prediction of immunmodulatory effects. Toxicology Letters238, S230-S230
[2] Zwicker, P., Schultze, N., Niehs, S., Methling, K., Wurster, M., Bernhardt, J., Drwal, M., Nickel, J., Dunkel, M., Wachlin, G., Lalk, M., Preissner, R., Lindequist, U., and Haertel, B. (2015) An in vitro approach for evaluating the immunotoxic potential of Cannabidiol. Toxicology Letters238, S221-S221
[3] Surmann, K., Simon, M., Hildebrandt, P., Pfoertner, H., Michalik, S., Stentzel, S., Steil, L., Dhople, V. M., Bernhardt, J., Schlueter, R., Depke, M., Gierok, P., Lalk, M., Broeker, B. M., Schmidt, F., and Voelker, U. (2015) A proteomic perspective of the interplay of Staphylococcus aureus and human alveolar epithelial cells during infection. Journal of Proteomics128, 203-217
[4] Siegmund, W., Modess, C., Scheuch, E., Methling, K., Keiser, M., Nassif, A., Rosskopf, D., Bednarski, P. J., Borlak, J., and Terhaag, B. (2015) Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1. British Journal of Clinical Pharmacology79, 501-513
[5] Schultze, N., Zwicker, P., Niehs, S., Methling, K., Wurster, M., Bernhardt, J., Drwa, M., Nickel, J., Dunkel, M., Wachlin, G., Lalk, M., Preissner, R., Lindequist, U., and Haertel, B. (2015) Evaluation of the immunotoxic potential of Tulipalin A by a combination of functional in-vitro investigations and omics analyses. Toxicology Letters238, S221-S221
[6] Scheuch, E., Methling, K., Bednarski, P. J., Oswald, S., and Siegmund, W. (2015) Quantitative LC-MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man. Journal of Pharmaceutical and Biomedical Analysis102, 377-385
[7] Pane-Farre, C. A., Alius, M. G., Modess, C., Methling, K., Blumenthal, T., and Hamm, A. O. (2015) Anxiety sensitivity and expectation of arousal differentially affect the respiratory response to caffeine. Psychopharmacology232, 1931-1939
[8] Cecil, A., Ohlsen, K., Menzel, T., Francois, P., Schrenzel, J., Fischer, A., Doerries, K., Selle, M., Lalk, M., Hantzschmann, J., Dittrich, M., Liang, C., Bernhardt, J., Oelschlaeger, T. A., Bringmann, G., Bruhn, H., Unger, M., Ponte-Sucre, A., Lehmann, L., and Dandekar, T. (2015) Modelling antibiotic and cytotoxic isoquinoline effects in Staphylococcus aureus, Staphylococcus epidermidis and mammalian cells. International Journal of Medical Microbiology305, 96-109
[1] Surmann, K., Michalik, S., Hildebrandt, P., Gierok, P., Depke, M., Brinkmann, L., Bernhardt, J., Salazar, M. G., Sun, Z., Shteynberg, D., Kusebauch, U., Moritz, R. L., Wollscheid, B., Lalk, M., Volker, U., and Schmidt, F. (2014) Comparative proteome analysis reveals conserved and specific adaptation patterns of Staphylococcus aureus after internalization by different types of human non-professional phagocytic host cells. Front Microbiol5, 392
[2] Schulz, C., Gierok, P., Petruschka, L., Lalk, M., Mader, U., and Hammerschmidt, S. (2014) Regulation of the arginine deiminase system by ArgR2 interferes with arginine metabolism and fitness of Streptococcus pneumoniae. MBio5
[3] Meyer, H., Weidmann, H., Mader, U., Hecker, M., Volker, U., and Lalk, M. (2014) A time resolved metabolomics study: the influence of different carbon sources during growth and starvation of Bacillus subtilis. Mol Biosyst10, 1812-23
[4] Liebeke, M., and Lalk, M. (2014) Staphylococcus aureus metabolic response to changing environmental conditions - a metabolomics perspective. Int J Med Microbiol304, 222-9
[5] Krismer, B., Liebeke, M., Janek, D., Nega, M., Rautenberg, M., Hornig, G., Unger, C., Weidenmaier, C., Lalk, M., and Peschel, A. (2014) Nutrient limitation governs Staphylococcus aureus metabolism and niche adaptation in the human nose. PLoS Pathog10, e1003862
[6] Kohlstedt, M., Sappa, P. K., Meyer, H., Maass, S., Zaprasis, A., Hoffmann, T., Becker, J., Steil, L., Hecker, M., van Dijl, J. M., Lalk, M., Mader, U., Stulke, J., Bremer, E., Volker, U., and Wittmann, C. (2014) Adaptation of Bacillus subtilis carbon core metabolism to simultaneous nutrient limitation and osmotic challenge: a multi-omics perspective. Environ Microbiol16, 1898-917
[7] Handtke, S., Volland, S., Methling, K., Albrecht, D., Becher, D., Nehls, J., Bongaerts, J., Maurer, K. H., Lalk, M., Liesegang, H., Voigt, B., Daniel, R., and Hecker, M. (2014) Cell physiology of the biotechnological relevant bacterium Bacillus pumilus-an omics-based approach. J Biotechnol192 Pt A, 204-14
[8] Handtke, S., Schroeter, R., Jurgen, B., Methling, K., Schluter, R., Albrecht, D., van Hijum, S. A., Bongaerts, J., Maurer, K. H., Lalk, M., Schweder, T., Hecker, M., and Voigt, B. (2014) Bacillus pumilus reveals a remarkably high resistance to hydrogen peroxide provoked oxidative stress. PLoS One9, e85625
[9] Gierok, P., Harms, M., Richter, E., Hildebrandt, J. P., Lalk, M., Mostertz, J., and Hochgrafe, F. (2014) Staphylococcus aureus alpha-toxin mediates general and cell type-specific changes in metabolite concentrations of immortalized human airway epithelial cells. PLoS One9, e94818
[10] Fischer, A., Kambara, K., Meyer, H., Stenz, L., Bonetti, E. J., Girard, M., Lalk, M., Francois, P., and Schrenzel, J. (2014) GdpS contributes to Staphylococcus aureus biofilm formation by regulation of eDNA release. Int J Med Microbiol304, 284-99
[11] Dorries, K., Schlueter, R., and Lalk, M. (2014) Impact of antibiotics with various target sites on the metabolome of Staphylococcus aureus. Antimicrob Agents Chemother58, 7151-63
[1] Schroeter, R., Hoffmann, T., Voigt, B., Meyer, H., Bleisteiner, M., Muntel, J., Jurgen, B., Albrecht, D., Becher, D., Lalk, M., Evers, S., Bongaerts, J., Maurer, K. H., Putzer, H., Hecker, M., Schweder, T., and Bremer, E. (2013) Stress responses of the industrial work horse Bacillus licheniformis to osmotic challenges. PLoS One8, e80956
[2] Pother, D. C., Gierok, P., Harms, M., Mostertz, J., Hochgrafe, F., Antelmann, H., Hamilton, C. J., Borovok, I., Lalk, M., Aharonowitz, Y., and Hecker, M. (2013) Distribution and infection-related functions of bacillithiol in Staphylococcus aureus. Int J Med Microbiol303, 114-23
[3] Kabisch, J., Pratzka, I., Meyer, H., Albrecht, D., Lalk, M., Ehrenreich, A., and Schweder, T. (2013) Metabolic engineering of Bacillus subtilis for growth on overflow metabolites. Microb Cell Fact12, 72
[4] Mader, D., Liebeke, M., Winstel, V., Methling, K., Leibig, M., Gotz, F., Lalk, M., and Peschel, A. (2013) Role of N-terminal protein formylation in central metabolic processes in Staphylococcus aureus. BMC Microbiol13, 7
[5] Dorries, K., and Lalk, M. (2013) Metabolic footprint analysis uncovers strain specific overflow metabolism and D-isoleucine production of Staphylococcus aureus COL and HG001. PLoS One8, e81500
[6] Becker, J., Reinefeld, J., Stellmacher, R., Schafer, R., Lange, A., Meyer, H., Lalk, M., Zelder, O., von Abendroth, G., Schroder, H., Haefner, S., and Wittmann, C. (2013) Systems-wide analysis and engineering of metabolic pathway fluxes in bio-succinate producing Basfia succiniciproducens. Biotechnol Bioeng110, 3013-23
[1] Reiss, S., Pane-Farre, J., Fuchs, S., Francois, P., Liebeke, M., Schrenzel, J., Lindequist, U., Lalk, M., Wolz, C., Hecker, M., and Engelmann, S. (2012) Global analysis of the Staphylococcus aureus response to mupirocin. Antimicrob Agents Chemother56, 787-804
[2] Mikolasch, A., Manda, K., Schluter, R., Lalk, M., Witt, S., Seefeldt, S., Hammer, E., Schauer, F., Julich, W. D., and Lindequist, U. (2012) Comparative analyses of laccase-catalyzed amination reactions for production of novel beta-lactam antibiotics. Biotechnol Appl Biochem59, 295-306
[3] Michalik, S., Bernhardt, J., Otto, A., Moche, M., Becher, D., Meyer, H., Lalk, M., Schurmann, C., Schluter, R., Kock, H., Gerth, U., and Hecker, M. (2012) Life and death of proteins: a case study of glucose-starved Staphylococcus aureus. Mol Cell Proteomics11, 558-70
[4] Birkenstock, T., Liebeke, M., Winstel, V., Krismer, B., Gekeler, C., Niemiec, M. J., Bisswanger, H., Lalk, M., and Peschel, A. (2012) Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenylbismuthdichloride in multiresistant bacterial pathogens. J Biol Chem287, 2887-95
[5] Kleiner, M., Wentrup, C., Lott, C., Teeling, H., Wetzel, S., Young, J., Chang, Y. J., Shah, M., VerBerkmoes, N. C., Zarzycki, J., Fuchs, G., Markert, S., Hempel, K., Voigt, B., Becher, D., Liebeke, M., Lalk, M., Albrecht, D., Hecker, M., Schweder, T., and Dubilier, N. (2012) Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use. Proc Natl Acad Sci U S A109, E1173-82
[6] Hartel, T., Eylert, E., Schulz, C., Petruschka, L., Gierok, P., Grubmuller, S., Lalk, M., Eisenreich, W., and Hammerschmidt, S. (2012) Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling. J Biol Chem287, 4260-74
[7] Geiger, T., Francois, P., Liebeke, M., Fraunholz, M., Goerke, C., Krismer, B., Schrenzel, J., Lalk, M., and Wolz, C. (2012) The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression. PLoS Pathog8, e1003016
[1] Schroeter, R., Voigt, B., Jurgen, B., Methling, K., Pother, D. C., Schafer, H., Albrecht, D., Mostertz, J., Mader, U., Evers, S., Maurer, K. H., Lalk, M., Mascher, T., Hecker, M., and Schweder, T. (2011) The peroxide stress response of Bacillus licheniformis. Proteomics11, 2851-66
[2] Leibig, M., Liebeke, M., Mader, D., Lalk, M., Peschel, A., and Gotz, F. (2011) Pyruvate formate lyase acts as a formate supplier for metabolic processes during anaerobiosis in Staphylococcus aureus. J Bacteriol193, 952-62
[3] Liang, C., Liebeke, M., Schwarz, R., Zuhlke, D., Fuchs, S., Menschner, L., Engelmann, S., Wolz, C., Jaglitz, S., Bernhardt, J., Hecker, M., Lalk, M., and Dandekar, T. (2011) Staphylococcus aureus physiological growth limitations: insights from flux calculations built on proteomics and external metabolite data. Proteomics11, 1915-35
[1] Wilmes, B., Hartung, A., Lalk, M., Liebeke, M., Schweder, T., and Neubauer, P. (2010) Fed-batch process for the psychrotolerant marine bacterium Pseudoalteromonas haloplanktis. Microb Cell Fact9, 72
[2] Thanh, T. N., Jurgen, B., Bauch, M., Liebeke, M., Lalk, M., Ehrenreich, A., Evers, S., Maurer, K. H., Antelmann, H., Ernst, F., Homuth, G., Hecker, M., and Schweder, T. (2010) Regulation of acetoin and 2,3-butanediol utilization in Bacillus licheniformis. Appl Microbiol Biotechnol87, 2227-35
[3] Reszka, P., Schulz, R., Methling, K., Lalk, M., and Bednarski, P. J. (2010) Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substrates. ChemMedChem5, 103-17
[4] Pagels, M., Fuchs, S., Pane-Farre, J., Kohler, C., Menschner, L., Hecker, M., McNamarra, P. J., Bauer, M. C., von Wachenfeldt, C., Liebeke, M., Lalk, M., Sander, G., von Eiff, C., Proctor, R. A., and Engelmann, S. (2010) Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus. Mol Microbiol76, 1142-61
[5] Otto, A., Bernhardt, J., Meyer, H., Schaffer, M., Herbst, F. A., Siebourg, J., Mader, U., Lalk, M., Hecker, M., and Becher, D. (2010) Systems-wide temporal proteomic profiling in glucose-starved Bacillus subtilis. Nat Commun1, 137
[6] Mikolasch, A., Hahn, V., Manda, K., Pump, J., Illas, N., Gordes, D., Lalk, M., Gesell Salazar, M., Hammer, E., Julich, W. D., Rawer, S., Thurow, K., Lindequist, U., and Schauer, F. (2010) Laccase-catalyzed cross-linking of amino acids and peptides with dihydroxylated aromatic compounds. Amino Acids39, 671-83
[7] Meyer, H., Liebeke, M., and Lalk, M. (2010) A protocol for the investigation of the intracellular Staphylococcus aureus metabolome. Anal Biochem401, 250-9
[8] Liebeke, M., Wunder, A., and Lalk, M. (2010) A rapid microwave-assisted derivatization of bacterial metabolome samples for gas chromatography/mass spectrometry analysis. Anal Biochem401, 312-4
[9] Liebeke, M., Meyer, H., Donat, S., Ohlsen, K., and Lalk, M. (2010) A metabolomic view of Staphylococcus aureus and its ser/thr kinase and phosphatase deletion mutants: involvement in cell wall biosynthesis. Chem Biol17, 820-30
[10] Geiger, T., Goerke, C., Fritz, M., Schafer, T., Ohlsen, K., Liebeke, M., Lalk, M., and Wolz, C. (2010) Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus. Infect Immun78, 1873-83
[11] Gaupp, R., Schlag, S., Liebeke, M., Lalk, M., and Gotz, F. (2010) Advantage of upregulation of succinate dehydrogenase in Staphylococcus aureus biofilms. J Bacteriol192, 2385-94
[1] Zainuddin, E. N., Jansen, R., Nimtz, M., Wray, V., Preisitsch, M., Lalk, M., and Mundt, S. (2009) Lyngbyazothrins A-D, antimicrobial cyclic undecapeptides from the cultured Cyanobacterium lyngbya sp. J Nat Prod72, 1373-8
[2] Waldau, D., Mikolasch, A., Lalk, M., and Schauer, F. (2009) Derivatization of bioactive carbazoles by the biphenyl-degrading bacterium Ralstonia sp. strain SBUG 290. Appl Microbiol Biotechnol83, 67-75
[3] Riahi, A., Wurster, M., Lalk, M., Lindequist, U., and Langer, P. (2009) Synthesis and antimicrobial activity of 4-hydroxy-4-(pyridyl)alk- 3-en-2-ones. Bioorg Med Chem17, 4323-6
[4] Pother, D. C., Liebeke, M., Hochgrafe, F., Antelmann, H., Becher, D., Lalk, M., Lindequist, U., Borovok, I., Cohen, G., Aharonowitz, Y., and Hecker, M. (2009) Diamide triggers mainly S Thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus aureus. J Bacteriol 191, 7520-30
[5] Nguyen, T. T., Eiamphungporn, W., Mader, U., Liebeke, M., Lalk, M., Hecker, M., Helmann, J. D., and Antelmann, H. (2009) Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR). Mol Microbiol71, 876-94
[6] Michalik, S., Liebeke, M., Zuhlke, D., Lalk, M., Bernhardt, J., Gerth, U., and Hecker, M. (2009) Proteolysis during long-term glucose starvation in Staphylococcus aureus COL. Proteomics9, 4468-77
[7] Methling, K., Reszka, P., Lalk, M., Vrana, O., Scheuch, E., Siegmund, W., Terhaag, B., and Bednarski, P. J. (2009) Investigation of the in vitro metabolism of the analgesic flupirtine. Drug Metab Dispos37, 479-93
[8] Liebeke, M., Brozel, V. S., Hecker, M., and Lalk, M. (2009) Chemical characterization of soil extract as growth media for the ecophysiological study of bacteria. Appl Microbiol Biotechnol83, 161-73
[9] Donat, S., Streker, K., Schirmeister, T., Rakette, S., Stehle, T., Liebeke, M., Lalk, M., and Ohlsen, K. (2009) Transcriptome and functional analysis of the eukaryotic-type serine/threonine kinase PknB in Staphylococcus aureus. J Bacteriol191, 4056-69
[1] Schlag, S., Fuchs, S., Nerz, C., Gaupp, R., Engelmann, S., Liebeke, M., Lalk, M., Hecker, M., and Gotz, F. (2008) Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus. J Bacteriol190, 7847-58
[2] Mikolasch, A., Wurster, M., Lalk, M., Witt, S., Seefeldt, S., Hammer, E., Schauer, F., Julich, W. D., and Lindequist, U. (2008) Novel beta-lactam antibiotics synthesized by amination of catechols using fungal laccase. Chem Pharm Bull (Tokyo)56, 902-7
[3] Mikolasch, A., Matthies, A., Lalk, M., and Schauer, F. (2008) Laccase-induced C-N coupling of substituted p-hydroquinones with p-aminobenzoic acid in comparison with known chemical routes. Appl Microbiol Biotechnol80, 389-97
[4] Liebeke, M., Pother, D. C., van Duy, N., Albrecht, D., Becher, D., Hochgrafe, F., Lalk, M., Hecker, M., and Antelmann, H. (2008) Depletion of thiol-containing proteins in response to quinones in Bacillus subtilis. Mol Microbiol69, 1513-29
[5] Libnow, S., Methling, K., Hein, M., Michalik, D., Harms, M., Wende, K., Flemming, A., Kockerling, M., Reinke, H., Bednarski, P. J., Lalk, M., and Langer, P. (2008) Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines. Bioorg Med Chem16, 5570-83
[6] Kohler, C., von Eiff, C., Liebeke, M., McNamara, P. J., Lalk, M., Proctor, R. A., Hecker, M., and Engelmann, S. (2008) A defect in menadione biosynthesis induces global changes in gene expression in Staphylococcus aureus. J Bacteriol190, 6351-64
[7] Hussain, I., Yawer, M. A., Lalk, M., Lindequist, U., Villinger, A., Fischer, C., and Langer, P. (2008) Hetero-Diels-Alder reaction of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with arylsulfonylcyanides. Synthesis and antimicrobial activity of 4-hydroxy- 2-(arylsulfonyl)pyridines. Bioorg Med Chem16, 9898-903
[8] Hoettecke, N., Rotzoll, S., Albrecht, U., Lalk, M., Fischer, C., and Langer, P. (2008) Synthesis and antimicrobial activity of 2-alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones and 2-alkenylquinol-4-ones. Bioorg Med Chem16, 10319-25
[9] Hochgrafe, F., Wolf, C., Fuchs, S., Liebeke, M., Lalk, M., Engelmann, S., and Hecker, M. (2008) Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus. J Bacteriol190, 4997-5008
[10] Driller, K. M., Libnow, S., Hein, M., Harms, M., Wende, K., Lalk, M., Michalik, D., Reinke, H., and Langer, P. (2008) Synthesis of 6H-indolo[2,3-b]quinoxaline-N-glycosides and their cytotoxic activity against human ceratinocytes (HaCaT). Org Biomol Chem6, 4218-23
[1] Zainuddin, E. N., Mentel, R., Wray, V., Jansen, R., Nimtz, M., Lalk, M., and Mundt, S. (2007) Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe. J Nat Prod70, 1084-8
[2] Rahn, T., Nguyen, V. T., Dang, T. H., Ahmed, Z., Methling, K., Lalk, M., Fischer, C., Spannenberg, A., and Langer, P. (2007) Synthesis of 1,3,5-tricarbonyl derivatives by condensation of 1,3-bis(silyl enol ethers) with acid chlorides. J Org Chem72, 1957-61
[3] Nguyen, V. D., Wolf, C., Mader, U., Lalk, M., Langer, P., Lindequist, U., Hecker, M., and Antelmann, H. (2007) Transcriptome and proteome analyses in response to 2-methylhydroquinone and 6-brom-2-vinyl-chroman-4-on reveal different degradation systems involved in the catabolism of aromatic compounds in Bacillus subtilis. Proteomics7, 1391-408
[4] Mikolasch, A., Niedermeyer, T. H., Lalk, M., Witt, S., Seefeldt, S., Hammer, E., Schauer, F., Gesell Salazar, M., Hessel, S., Julich, W. D., and Lindequist, U. (2007) Novel cephalosporins synthesized by amination of 2,5-dihydroxybenzoic acid derivatives using fungal laccases II. Chem Pharm Bull (Tokyo)55, 412-6
[1] Poeckel, D., Niedermeyer, T. H., Pham, H. T., Mikolasch, A., Mundt, S., Lindequist, U., Lalk, M., and Werz, O. (2006) Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones. Med Chem2, 591-5
[2] Neumann, H., Strubing, D., Lalk, M., Klaus, S., Hubner, S., Spannenberg, A., Lindequist, U., and Beller, M. (2006) Synthesis and antimicrobial activity of N-analogous corollosporines. Org Biomol Chem4, 1365-75
[3] Mikolasch, A., Niedermeyer, T. H., Lalk, M., Witt, S., Seefeldt, S., Hammer, E., Schauer, F., Gesell, M., Hessel, S., Julich, W. D., and Lindequist, U. (2006) Novel penicillins synthesized by biotransformation using laccase from Trametes spec. Chem Pharm Bull (Tokyo)54, 632-8
[4] Bose, G., Bracht, K., Bednarski, P. J., Lalk, M., and Langer, P. (2006) Synthesis, reactions and structure-activity relationships of 1-hydroxyspiro[2.5]cyclooct-4-en-3-ones: illudin analogs with in vitro cytotoxic activity. Bioorg Med Chem14, 4694-703
[1] Schweder, T., Lindequist, U., and Lalk, M. (2005) Screening for new metabolites from marine microorganisms. Adv Biochem Eng Biotechnol96, 1-48
[2] Niedermeyer, T. H., Mikolasch, A., and Lalk, M. (2005) Nuclear amination catalyzed by fungal laccases: reaction products of p-hydroquinones and primary aromatic amines. J Org Chem70, 2002-8
[3] Niedermeyer, T. H., Lindequist, U., Mentel, R., Gordes, D., Schmidt, E., Thurow, K., and Lalk, M. (2005) Antiviral Terpenoid Constituents of Ganoderma pfeifferi. J Nat Prod68, 1728-31
[4] Albrecht, U., Lalk, M., and Langer, P. (2005) Synthesis and structure-activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents. Bioorg Med Chem13, 1531-6
[5] Albrecht, U., Gordes, D., Schmidt, E., Thurow, K., Lalk, M., and Langer, P. (2005) Synthesis and structure-activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents. Bioorg Med Chem13, 4402-7
[1] Bansemir, A., Just, N., Michalik, M., Lindequist, U., and Lalk, M. (2004) Extracts and sesquiterpene derivatives from the red alga Laurencia chondrioides with antibacterial activity against fish and human pathogenic bacteria. Chem Biodivers1, 463-7