Publications

2018
[1]Viana F, Paz LC, Methling K, Damgaard CF, Lalk M, Schramm A, Lund MB. (2018) Distinct effects of the nephridial symbionts Verminephrobacter and Candidatus Nephrothrix on reproduction and maturation of its earthworm host Eisenia andrei. FEMS Microbiol Ecol. 2018 Feb 1;94(2). doi: 10.1093/femsec/fix178.
[2]Leonard A, Gierok P, Methling K, Gómez-Mejia A, Hammerschmidt S, Lalk M. (2018) Metabolic inventory of Streptococcus pneumoniae growing in a chemical defined environment. Int J Med Microbiol. 2018 Jan 3. pii: S1438-4221(17)30487-3. doi: 10.1016/j.ijmm.2018.01.001.
2017
[1]Zwicker P, Schultze N, Niehs S, Albrecht D, Methling K, Wurster M, Wachlin G, Lalk M, Lindequist U, Haertel B. (2017) Differential effects of Helenalin, an anti-inflammatory sesquiterpene lactone, on the proteome, metabolome and the oxidative stress response in several immune cell types. Toxicol In Vitro. 2017 Apr;40:45-54. doi: 10.1016/j.tiv.2016.12.010.
[2]Zühlke MK, Schlüter R, Mikolasch A, Zühlke D, Giersberg M, Schindler H, Henning AK, Frenzel H, Hammer E, Lalk M, Bornscheuer UT, Riedel K, Kunze G, Schauer F. (2017) Biotransformation and reduction of estrogenicity of bisphenol A by the biphenyl-degrading Cupriavidus basilensis. Appl Microbiol Biotechnol. 2017 May;101(9):3743-3758. doi: 10.1007/s00253-016-8061-z.
[3]Dhali D, Coutte F, Arias AA, Auger S, Bidnenko V, Chataigné G, Lalk M, Niehren J, de Sousa J, Versari C, Jacques P. (2017) Genetic engineering of the branched fatty acid metabolic pathway of Bacillus subtilis for the overproduction of surfactin C14 isoform. Biotechnol J. 2017 Jul;12(7). doi: 10.1002/biot.201600574.
[4]Shahi P, Trebicz-Geffen M, Nagaraja S, Hertz R, Baumel-Alterzon S, Methling K, Lalk M, Mazumder M, Samudrala G, Ankri S. (2017) N-acetyl ornithine deacetylase is a moonlighting protein and is involved in the adaptation of Entamoeba histolytica to nitrosative stress. Sci Rep. 2017 Apr 5;7:45802. doi: 10.1038/srep45802.
[5]Ashraf K, Yasrebi K, Hertlein T, Ohlsen K, Lalk M, Hilgeroth A. (2017) Novel Effective Small-Molecule Antibacterials against Enterococcus Strains. Molecules. 2017 Dec 10;22(12). pii: E2193. doi: 10.3390/molecules22122193.
[6]Schultz D, Schlüter R, Gerth U, Lalk M. (2017) Metabolic Perturbations in a Bacillus subtilis clpP Mutant during Glucose Starvation. Metabolites 7(4), 63; doi: 10.3390/metabo7040063
2016
[1]Uifalean, A., Schneider, S., Ionescu, C., Lalk, M., and Iuga, C. A. (2016) Soy Isoflavones and Breast Cancer Cell Lines: Molecular Mechanisms and Future Perspectives. Molecules 21
[2]Shahi, P., Trebicz-Geffen, M., Nagaraja, S., Alterzon-Baumel, S., Hertz, R., Methling, K., Lalk, M., and Ankri, S. (2016) Proteomic Identification of Oxidized Proteins in Entamoeba histolytica by Resin-Assisted Capture: Insights into the Role of Arginase in Resistance to Oxidative Stress. PLoS neglected tropical diseases 10
[3]Kumpfmueller, J., Methling, K., Fang, L., Pfeifer, B. A., Lalk, M., and Schweder, T. (2016) Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis. Applied Microbiology and Biotechnology 100, 1209-1220
[4]Gierok, P., Kohler, C., Steinmetz, I., and Lalk, M. (2016) Burkholderia pseudomallei Colony Morphotypes Show a Synchronized Metabolic Pattern after Acute Infection. PLoS neglected tropical diseases 10, e0004483-e0004483
[5]Alresly, Z., Lindequist, U., Lalk, M., Porzel, A., Arnold, N., and Wessjohann, L. A. (2016) Bioactive Triterpenes from the Fungus Piptoporus betulinus. Records of Natural Products 10, 103-108
[6]Gierok P, Harms M, Methling K, Hochgräfe F, Lalk M. (2016) Staphylococcus aureus Infection Reduces Nutrition Uptake and Nucleotide Biosynthesis in a Human Airway Epithelial Cell Line. Metabolites 6(4) 41. doi: 10.3390/metabo6040041
[7]Zühlke D, Dörries K, Bernhardt J, Maas S, Muntel J, Liebscher V, Panne-Farre J, Riedel K, Lalk M, Völker U, Engelmann S, Becher D, Fuchs S, Hecker M. (2016) Costs of life - Dynamics of the protein inventory of Staphylococcus aureus during anaerobiosis. Sci Rep. 6, 28172, doi: 10.1038/srep28172
2015
[1]Zwicker, P., Schultze, N., Niehs, S., Methling, K., Wurster, M., Bernhardt, J., Wachlin, G., Lalk, M., Preissner, R., Lindequist, U., and Haertel, B. (2015) Omics technologies for the prediction of immunmodulatory effects. Toxicology Letters 238, S230-S230
[2]Zwicker, P., Schultze, N., Niehs, S., Methling, K., Wurster, M., Bernhardt, J., Drwal, M., Nickel, J., Dunkel, M., Wachlin, G., Lalk, M., Preissner, R., Lindequist, U., and Haertel, B. (2015) An in vitro approach for evaluating the immunotoxic potential of Cannabidiol. Toxicology Letters 238, S221-S221
[3]Surmann, K., Simon, M., Hildebrandt, P., Pfoertner, H., Michalik, S., Stentzel, S., Steil, L., Dhople, V. M., Bernhardt, J., Schlueter, R., Depke, M., Gierok, P., Lalk, M., Broeker, B. M., Schmidt, F., and Voelker, U. (2015) A proteomic perspective of the interplay of Staphylococcus aureus and human alveolar epithelial cells during infection. Journal of Proteomics 128, 203-217
[4]Siegmund, W., Modess, C., Scheuch, E., Methling, K., Keiser, M., Nassif, A., Rosskopf, D., Bednarski, P. J., Borlak, J., and Terhaag, B. (2015) Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1. British Journal of Clinical Pharmacology 79, 501-513
[5]Schultze, N., Zwicker, P., Niehs, S., Methling, K., Wurster, M., Bernhardt, J., Drwa, M., Nickel, J., Dunkel, M., Wachlin, G., Lalk, M., Preissner, R., Lindequist, U., and Haertel, B. (2015) Evaluation of the immunotoxic potential of Tulipalin A by a combination of functional in-vitro investigations and omics analyses. Toxicology Letters 238, S221-S221
[6]Scheuch, E., Methling, K., Bednarski, P. J., Oswald, S., and Siegmund, W. (2015) Quantitative LC-MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man. Journal of Pharmaceutical and Biomedical Analysis 102, 377-385
[7]Pane-Farre, C. A., Alius, M. G., Modess, C., Methling, K., Blumenthal, T., and Hamm, A. O. (2015) Anxiety sensitivity and expectation of arousal differentially affect the respiratory response to caffeine. Psychopharmacology 232, 1931-1939
[8]Cecil, A., Ohlsen, K., Menzel, T., Francois, P., Schrenzel, J., Fischer, A., Doerries, K., Selle, M., Lalk, M., Hantzschmann, J., Dittrich, M., Liang, C., Bernhardt, J., Oelschlaeger, T. A., Bringmann, G., Bruhn, H., Unger, M., Ponte-Sucre, A., Lehmann, L., and Dandekar, T. (2015) Modelling antibiotic and cytotoxic isoquinoline effects in Staphylococcus aureus, Staphylococcus epidermidis and mammalian cells. International Journal of Medical Microbiology 305, 96-109
2014
[1]Surmann, K., Michalik, S., Hildebrandt, P., Gierok, P., Depke, M., Brinkmann, L., Bernhardt, J., Salazar, M. G., Sun, Z., Shteynberg, D., Kusebauch, U., Moritz, R. L., Wollscheid, B., Lalk, M., Volker, U., and Schmidt, F. (2014) Comparative proteome analysis reveals conserved and specific adaptation patterns of Staphylococcus aureus after internalization by different types of human non-professional phagocytic host cells. Front Microbiol 5, 392
[2]Schulz, C., Gierok, P., Petruschka, L., Lalk, M., Mader, U., and Hammerschmidt, S. (2014) Regulation of the arginine deiminase system by ArgR2 interferes with arginine metabolism and fitness of Streptococcus pneumoniae. MBio 5
[3]Meyer, H., Weidmann, H., Mader, U., Hecker, M., Volker, U., and Lalk, M. (2014) A time resolved metabolomics study: the influence of different carbon sources during growth and starvation of Bacillus subtilis. Mol Biosyst 10, 1812-23
[4]Liebeke, M., and Lalk, M. (2014) Staphylococcus aureus metabolic response to changing environmental conditions - a metabolomics perspective. Int J Med Microbiol 304, 222-9
[5]Krismer, B., Liebeke, M., Janek, D., Nega, M., Rautenberg, M., Hornig, G., Unger, C., Weidenmaier, C., Lalk, M., and Peschel, A. (2014) Nutrient limitation governs Staphylococcus aureus metabolism and niche adaptation in the human nose. PLoS Pathog 10, e1003862
[6]Kohlstedt, M., Sappa, P. K., Meyer, H., Maass, S., Zaprasis, A., Hoffmann, T., Becker, J., Steil, L., Hecker, M., van Dijl, J. M., Lalk, M., Mader, U., Stulke, J., Bremer, E., Volker, U., and Wittmann, C. (2014) Adaptation of Bacillus subtilis carbon core metabolism to simultaneous nutrient limitation and osmotic challenge: a multi-omics perspective. Environ Microbiol 16, 1898-917
[7]Handtke, S., Volland, S., Methling, K., Albrecht, D., Becher, D., Nehls, J., Bongaerts, J., Maurer, K. H., Lalk, M., Liesegang, H., Voigt, B., Daniel, R., and Hecker, M. (2014) Cell physiology of the biotechnological relevant bacterium Bacillus pumilus-an omics-based approach. J Biotechnol 192 Pt A, 204-14
[8]Handtke, S., Schroeter, R., Jurgen, B., Methling, K., Schluter, R., Albrecht, D., van Hijum, S. A., Bongaerts, J., Maurer, K. H., Lalk, M., Schweder, T., Hecker, M., and Voigt, B. (2014) Bacillus pumilus reveals a remarkably high resistance to hydrogen peroxide provoked oxidative stress. PLoS One 9, e85625
[9]Gierok, P., Harms, M., Richter, E., Hildebrandt, J. P., Lalk, M., Mostertz, J., and Hochgrafe, F. (2014) Staphylococcus aureus alpha-toxin mediates general and cell type-specific changes in metabolite concentrations of immortalized human airway epithelial cells. PLoS One 9, e94818
[10]Fischer, A., Kambara, K., Meyer, H., Stenz, L., Bonetti, E. J., Girard, M., Lalk, M., Francois, P., and Schrenzel, J. (2014) GdpS contributes to Staphylococcus aureus biofilm formation by regulation of eDNA release. Int J Med Microbiol 304, 284-99
[11]Dorries, K., Schlueter, R., and Lalk, M. (2014) Impact of antibiotics with various target sites on the metabolome of Staphylococcus aureus. Antimicrob Agents Chemother 58, 7151-63
2013
[1]Schroeter, R., Hoffmann, T., Voigt, B., Meyer, H., Bleisteiner, M., Muntel, J., Jurgen, B., Albrecht, D., Becher, D., Lalk, M., Evers, S., Bongaerts, J., Maurer, K. H., Putzer, H., Hecker, M., Schweder, T., and Bremer, E. (2013) Stress responses of the industrial work horse Bacillus licheniformis to osmotic challenges. PLoS One 8, e80956
[2]Pother, D. C., Gierok, P., Harms, M., Mostertz, J., Hochgrafe, F., Antelmann, H., Hamilton, C. J., Borovok, I., Lalk, M., Aharonowitz, Y., and Hecker, M. (2013) Distribution and infection-related functions of bacillithiol in Staphylococcus aureus. Int J Med Microbiol 303, 114-23
[3]Kabisch, J., Pratzka, I., Meyer, H., Albrecht, D., Lalk, M., Ehrenreich, A., and Schweder, T. (2013) Metabolic engineering of Bacillus subtilis for growth on overflow metabolites. Microb Cell Fact 12, 72
[4]Mader, D., Liebeke, M., Winstel, V., Methling, K., Leibig, M., Gotz, F., Lalk, M., and Peschel, A. (2013) Role of N-terminal protein formylation in central metabolic processes in Staphylococcus aureus. BMC Microbiol 13, 7
[5]Dorries, K., and Lalk, M. (2013) Metabolic footprint analysis uncovers strain specific overflow metabolism and D-isoleucine production of Staphylococcus aureus COL and HG001. PLoS One 8, e81500
[6]Becker, J., Reinefeld, J., Stellmacher, R., Schafer, R., Lange, A., Meyer, H., Lalk, M., Zelder, O., von Abendroth, G., Schroder, H., Haefner, S., and Wittmann, C. (2013) Systems-wide analysis and engineering of metabolic pathway fluxes in bio-succinate producing Basfia succiniciproducens. Biotechnol Bioeng 110, 3013-23
2012
[1]Reiss, S., Pane-Farre, J., Fuchs, S., Francois, P., Liebeke, M., Schrenzel, J., Lindequist, U., Lalk, M., Wolz, C., Hecker, M., and Engelmann, S. (2012) Global analysis of the Staphylococcus aureus response to mupirocin. Antimicrob Agents Chemother 56, 787-804
[2]Mikolasch, A., Manda, K., Schluter, R., Lalk, M., Witt, S., Seefeldt, S., Hammer, E., Schauer, F., Julich, W. D., and Lindequist, U. (2012) Comparative analyses of laccase-catalyzed amination reactions for production of novel beta-lactam antibiotics. Biotechnol Appl Biochem 59, 295-306
[3]Michalik, S., Bernhardt, J., Otto, A., Moche, M., Becher, D., Meyer, H., Lalk, M., Schurmann, C., Schluter, R., Kock, H., Gerth, U., and Hecker, M. (2012) Life and death of proteins: a case study of glucose-starved Staphylococcus aureus. Mol Cell Proteomics 11, 558-70
[4]Birkenstock, T., Liebeke, M., Winstel, V., Krismer, B., Gekeler, C., Niemiec, M. J., Bisswanger, H., Lalk, M., and Peschel, A. (2012) Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenylbismuthdichloride in multiresistant bacterial pathogens. J Biol Chem 287, 2887-95
[5]Kleiner, M., Wentrup, C., Lott, C., Teeling, H., Wetzel, S., Young, J., Chang, Y. J., Shah, M., VerBerkmoes, N. C., Zarzycki, J., Fuchs, G., Markert, S., Hempel, K., Voigt, B., Becher, D., Liebeke, M., Lalk, M., Albrecht, D., Hecker, M., Schweder, T., and Dubilier, N. (2012) Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use. Proc Natl Acad Sci U S A 109, E1173-82
[6]Hartel, T., Eylert, E., Schulz, C., Petruschka, L., Gierok, P., Grubmuller, S., Lalk, M., Eisenreich, W., and Hammerschmidt, S. (2012) Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling. J Biol Chem 287, 4260-74
[7]Geiger, T., Francois, P., Liebeke, M., Fraunholz, M., Goerke, C., Krismer, B., Schrenzel, J., Lalk, M., and Wolz, C. (2012) The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression. PLoS Pathog 8, e1003016
2011
[1]Schroeter, R., Voigt, B., Jurgen, B., Methling, K., Pother, D. C., Schafer, H., Albrecht, D., Mostertz, J., Mader, U., Evers, S., Maurer, K. H., Lalk, M., Mascher, T., Hecker, M., and Schweder, T. (2011) The peroxide stress response of Bacillus licheniformis. Proteomics 11, 2851-66
[2]Leibig, M., Liebeke, M., Mader, D., Lalk, M., Peschel, A., and Gotz, F. (2011) Pyruvate formate lyase acts as a formate supplier for metabolic processes during anaerobiosis in Staphylococcus aureus. J Bacteriol 193, 952-62
[3]Liang, C., Liebeke, M., Schwarz, R., Zuhlke, D., Fuchs, S., Menschner, L., Engelmann, S., Wolz, C., Jaglitz, S., Bernhardt, J., Hecker, M., Lalk, M., and Dandekar, T. (2011) Staphylococcus aureus physiological growth limitations: insights from flux calculations built on proteomics and external metabolite data. Proteomics 11, 1915-35
2010
[1]Wilmes, B., Hartung, A., Lalk, M., Liebeke, M., Schweder, T., and Neubauer, P. (2010) Fed-batch process for the psychrotolerant marine bacterium Pseudoalteromonas haloplanktis. Microb Cell Fact 9, 72
[2]Thanh, T. N., Jurgen, B., Bauch, M., Liebeke, M., Lalk, M., Ehrenreich, A., Evers, S., Maurer, K. H., Antelmann, H., Ernst, F., Homuth, G., Hecker, M., and Schweder, T. (2010) Regulation of acetoin and 2,3-butanediol utilization in Bacillus licheniformis. Appl Microbiol Biotechnol 87, 2227-35
[3]Reszka, P., Schulz, R., Methling, K., Lalk, M., and Bednarski, P. J. (2010) Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substrates. ChemMedChem 5, 103-17
[4]Pagels, M., Fuchs, S., Pane-Farre, J., Kohler, C., Menschner, L., Hecker, M., McNamarra, P. J., Bauer, M. C., von Wachenfeldt, C., Liebeke, M., Lalk, M., Sander, G., von Eiff, C., Proctor, R. A., and Engelmann, S. (2010) Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus. Mol Microbiol 76, 1142-61
[5]Otto, A., Bernhardt, J., Meyer, H., Schaffer, M., Herbst, F. A., Siebourg, J., Mader, U., Lalk, M., Hecker, M., and Becher, D. (2010) Systems-wide temporal proteomic profiling in glucose-starved Bacillus subtilis. Nat Commun 1, 137
[6]Mikolasch, A., Hahn, V., Manda, K., Pump, J., Illas, N., Gordes, D., Lalk, M., Gesell Salazar, M., Hammer, E., Julich, W. D., Rawer, S., Thurow, K., Lindequist, U., and Schauer, F. (2010) Laccase-catalyzed cross-linking of amino acids and peptides with dihydroxylated aromatic compounds. Amino Acids 39, 671-83
[7]Meyer, H., Liebeke, M., and Lalk, M. (2010) A protocol for the investigation of the intracellular Staphylococcus aureus metabolome. Anal Biochem 401, 250-9
[8]Liebeke, M., Wunder, A., and Lalk, M. (2010) A rapid microwave-assisted derivatization of bacterial metabolome samples for gas chromatography/mass spectrometry analysis. Anal Biochem 401, 312-4
[9]Liebeke, M., Meyer, H., Donat, S., Ohlsen, K., and Lalk, M. (2010) A metabolomic view of Staphylococcus aureus and its ser/thr kinase and phosphatase deletion mutants: involvement in cell wall biosynthesis. Chem Biol 17, 820-30
[10]Geiger, T., Goerke, C., Fritz, M., Schafer, T., Ohlsen, K., Liebeke, M., Lalk, M., and Wolz, C. (2010) Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus. Infect Immun 78, 1873-83
[11]Gaupp, R., Schlag, S., Liebeke, M., Lalk, M., and Gotz, F. (2010) Advantage of upregulation of succinate dehydrogenase in Staphylococcus aureus biofilms. J Bacteriol 192, 2385-94
2009
[1]Zainuddin, E. N., Jansen, R., Nimtz, M., Wray, V., Preisitsch, M., Lalk, M., and Mundt, S. (2009) Lyngbyazothrins A-D, antimicrobial cyclic undecapeptides from the cultured Cyanobacterium lyngbya sp. J Nat Prod 72, 1373-8
[2]Waldau, D., Mikolasch, A., Lalk, M., and Schauer, F. (2009) Derivatization of bioactive carbazoles by the biphenyl-degrading bacterium Ralstonia sp. strain SBUG 290. Appl Microbiol Biotechnol 83, 67-75
[3]Riahi, A., Wurster, M., Lalk, M., Lindequist, U., and Langer, P. (2009) Synthesis and antimicrobial activity of 4-hydroxy-4-(pyridyl)alk- 3-en-2-ones. Bioorg Med Chem 17, 4323-6
[4]Pother, D. C., Liebeke, M., Hochgrafe, F., Antelmann, H., Becher, D., Lalk, M., Lindequist, U., Borovok, I., Cohen, G., Aharonowitz, Y., and Hecker, M. (2009) Diamide triggers mainly S Thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus aureus. J Bacteriol 191, 7520-30
[5]Nguyen, T. T., Eiamphungporn, W., Mader, U., Liebeke, M., Lalk, M., Hecker, M., Helmann, J. D., and Antelmann, H. (2009) Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR). Mol Microbiol 71, 876-94
[6]Michalik, S., Liebeke, M., Zuhlke, D., Lalk, M., Bernhardt, J., Gerth, U., and Hecker, M. (2009) Proteolysis during long-term glucose starvation in Staphylococcus aureus COL. Proteomics 9, 4468-77
[7]Methling, K., Reszka, P., Lalk, M., Vrana, O., Scheuch, E., Siegmund, W., Terhaag, B., and Bednarski, P. J. (2009) Investigation of the in vitro metabolism of the analgesic flupirtine. Drug Metab Dispos 37, 479-93
[8]Liebeke, M., Brozel, V. S., Hecker, M., and Lalk, M. (2009) Chemical characterization of soil extract as growth media for the ecophysiological study of bacteria. Appl Microbiol Biotechnol 83, 161-73
[9]Donat, S., Streker, K., Schirmeister, T., Rakette, S., Stehle, T., Liebeke, M., Lalk, M., and Ohlsen, K. (2009) Transcriptome and functional analysis of the eukaryotic-type serine/threonine kinase PknB in Staphylococcus aureus. J Bacteriol 191, 4056-69
2008
[1]Schlag, S., Fuchs, S., Nerz, C., Gaupp, R., Engelmann, S., Liebeke, M., Lalk, M., Hecker, M., and Gotz, F. (2008) Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus. J Bacteriol 190, 7847-58
[2]Mikolasch, A., Wurster, M., Lalk, M., Witt, S., Seefeldt, S., Hammer, E., Schauer, F., Julich, W. D., and Lindequist, U. (2008) Novel beta-lactam antibiotics synthesized by amination of catechols using fungal laccase. Chem Pharm Bull (Tokyo) 56, 902-7
[3]Mikolasch, A., Matthies, A., Lalk, M., and Schauer, F. (2008) Laccase-induced C-N coupling of substituted p-hydroquinones with p-aminobenzoic acid in comparison with known chemical routes. Appl Microbiol Biotechnol 80, 389-97
[4]Liebeke, M., Pother, D. C., van Duy, N., Albrecht, D., Becher, D., Hochgrafe, F., Lalk, M., Hecker, M., and Antelmann, H. (2008) Depletion of thiol-containing proteins in response to quinones in Bacillus subtilis. Mol Microbiol 69, 1513-29
[5]Libnow, S., Methling, K., Hein, M., Michalik, D., Harms, M., Wende, K., Flemming, A., Kockerling, M., Reinke, H., Bednarski, P. J., Lalk, M., and Langer, P. (2008) Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines. Bioorg Med Chem 16, 5570-83
[6]Kohler, C., von Eiff, C., Liebeke, M., McNamara, P. J., Lalk, M., Proctor, R. A., Hecker, M., and Engelmann, S. (2008) A defect in menadione biosynthesis induces global changes in gene expression in Staphylococcus aureus. J Bacteriol 190, 6351-64
[7]Hussain, I., Yawer, M. A., Lalk, M., Lindequist, U., Villinger, A., Fischer, C., and Langer, P. (2008) Hetero-Diels-Alder reaction of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with arylsulfonylcyanides. Synthesis and antimicrobial activity of 4-hydroxy- 2-(arylsulfonyl)pyridines. Bioorg Med Chem 16, 9898-903
[8]Hoettecke, N., Rotzoll, S., Albrecht, U., Lalk, M., Fischer, C., and Langer, P. (2008) Synthesis and antimicrobial activity of 2-alkenylchroman-4-ones, 2-alkenylthiochroman-4-ones and 2-alkenylquinol-4-ones. Bioorg Med Chem 16, 10319-25
[9]Hochgrafe, F., Wolf, C., Fuchs, S., Liebeke, M., Lalk, M., Engelmann, S., and Hecker, M. (2008) Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus. J Bacteriol 190, 4997-5008
[10]Driller, K. M., Libnow, S., Hein, M., Harms, M., Wende, K., Lalk, M., Michalik, D., Reinke, H., and Langer, P. (2008) Synthesis of 6H-indolo[2,3-b]quinoxaline-N-glycosides and their cytotoxic activity against human ceratinocytes (HaCaT). Org Biomol Chem 6, 4218-23
2007
[1]Zainuddin, E. N., Mentel, R., Wray, V., Jansen, R., Nimtz, M., Lalk, M., and Mundt, S. (2007) Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe. J Nat Prod 70, 1084-8
[2]Rahn, T., Nguyen, V. T., Dang, T. H., Ahmed, Z., Methling, K., Lalk, M., Fischer, C., Spannenberg, A., and Langer, P. (2007) Synthesis of 1,3,5-tricarbonyl derivatives by condensation of 1,3-bis(silyl enol ethers) with acid chlorides. J Org Chem 72, 1957-61
[3]Nguyen, V. D., Wolf, C., Mader, U., Lalk, M., Langer, P., Lindequist, U., Hecker, M., and Antelmann, H. (2007) Transcriptome and proteome analyses in response to 2-methylhydroquinone and 6-brom-2-vinyl-chroman-4-on reveal different degradation systems involved in the catabolism of aromatic compounds in Bacillus subtilis. Proteomics 7, 1391-408
[4]Mikolasch, A., Niedermeyer, T. H., Lalk, M., Witt, S., Seefeldt, S., Hammer, E., Schauer, F., Gesell Salazar, M., Hessel, S., Julich, W. D., and Lindequist, U. (2007) Novel cephalosporins synthesized by amination of 2,5-dihydroxybenzoic acid derivatives using fungal laccases II. Chem Pharm Bull (Tokyo) 55, 412-6
2006
[1]Poeckel, D., Niedermeyer, T. H., Pham, H. T., Mikolasch, A., Mundt, S., Lindequist, U., Lalk, M., and Werz, O. (2006) Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones. Med Chem 2, 591-5
[2]Neumann, H., Strubing, D., Lalk, M., Klaus, S., Hubner, S., Spannenberg, A., Lindequist, U., and Beller, M. (2006) Synthesis and antimicrobial activity of N-analogous corollosporines. Org Biomol Chem 4, 1365-75
[3]Mikolasch, A., Niedermeyer, T. H., Lalk, M., Witt, S., Seefeldt, S., Hammer, E., Schauer, F., Gesell, M., Hessel, S., Julich, W. D., and Lindequist, U. (2006) Novel penicillins synthesized by biotransformation using laccase from Trametes spec. Chem Pharm Bull (Tokyo) 54, 632-8
[4]Bose, G., Bracht, K., Bednarski, P. J., Lalk, M., and Langer, P. (2006) Synthesis, reactions and structure-activity relationships of 1-hydroxyspiro[2.5]cyclooct-4-en-3-ones: illudin analogs with in vitro cytotoxic activity. Bioorg Med Chem 14, 4694-703
2005
[1]Schweder, T., Lindequist, U., and Lalk, M. (2005) Screening for new metabolites from marine microorganisms. Adv Biochem Eng Biotechnol 96, 1-48
[2]Niedermeyer, T. H., Mikolasch, A., and Lalk, M. (2005) Nuclear amination catalyzed by fungal laccases: reaction products of p-hydroquinones and primary aromatic amines. J Org Chem 70, 2002-8
[3]Niedermeyer, T. H., Lindequist, U., Mentel, R., Gordes, D., Schmidt, E., Thurow, K., and Lalk, M. (2005) Antiviral Terpenoid Constituents of Ganoderma pfeifferi. J Nat Prod 68, 1728-31
[4]Albrecht, U., Lalk, M., and Langer, P. (2005) Synthesis and structure-activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents. Bioorg Med Chem 13, 1531-6
[5]Albrecht, U., Gordes, D., Schmidt, E., Thurow, K., Lalk, M., and Langer, P. (2005) Synthesis and structure-activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents. Bioorg Med Chem 13, 4402-7
2004
[1]Bansemir, A., Just, N., Michalik, M., Lindequist, U., and Lalk, M. (2004) Extracts and sesquiterpene derivatives from the red alga Laurencia chondrioides with antibacterial activity against fish and human pathogenic bacteria. Chem Biodivers 1, 463-7