Publications

• Meesaragandla, B., Blessing, D. O., Karanth, S., Rong, A., Geist, N., Delcea, M., "Interaction of polystyrene nanoparticles with supported lipid bilayers: Impact of nanoparticle size and protein corona" (2023), Macromolecular Bioscience, doi: 10.1002/mabi.202200464

• Nagel, F., Susemihl, A., Eulberg, T., Delcea, M., "Identification of Kazal Inhibitor Scaffolds with Identical Canonical Binding Loops and Their Effects on Binding Properties" (2023), Biochemistry, doi: 10.1021/acs.biochem.2c00573

• Geist, N., Nagel, F., Delcea, M., "Molecular interplay of ADAMTS13-MDTCS and von willebrand Factor-A2: deepened insights from extensive atomistic simulations" (2022), Journal of Biomolecular Structure and Dynamics, doi: 10.1080/07391102.2022.2135138

• Meesaragandla, B., Komaragiri, Y., Schlüter, R., Otto, O., Delcea, M., "The impact of cell culture media on the interaction of biopolymer-functionalized gold nanoparticles with cells: mechanical and toxicological properties" (2022), Scientific Reports, doi: 10.1038/s41598-022-20691-w

• Schulig, L., Geist, N., Delcea, M., Link, A., Kulke, M., "Fundamental Redesign of the TIGER2hs Kernel to Address Severe Parameter Sensitivity" (2022), Journal of Chemical Information and Modeling, doi: 10.1021/acs.jcim.2c00476

• Meesaragandla, B., Hayet, S., Fine, T., Janke, U., Chai, L., Delcea, M., "Inhibitory Effect of Epigallocatechin Gallate-Silver Nanoparticles and Their Lysozyme Bioconjugates on Biofilm Formation and Cytotoxicity" (2022), ACS Applied Bio Materials, doi: 10.1021/acsabm.2c00409

• Nagel, F., Susemihl, A., Geist, N., Möhlis, K., Palm, G. J., Lammers, M., Delcea, M., "Structural Basis of the Pancreatitis-Associated Autoproteolytic Failsafe Mechanism in Human Anionic Trypsin" (2022), Journal of Inflammation Research, doi: 10.2147/jir.s367699

• Nagel, F., Palm, G. J., Geist, N., McDonnell, T. C. R., Susemihl, A., Girbardt, B., Mayerle, J., Lerch, M. M., Lammers, M., Delcea, M., "Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin" (2022), International Journal of Molecular Sciences, doi: 10.3390/ijms23073468

• Susemihl, A., Nagel, F., Grabarczyk, P., Schmidt, C. A., Delcea, M., "Easy Expression and Purification of Fluorescent N-Terminal BCL11B CCHC Zinc Finger Domain" (2021), Molecules, doi: 10.3390/molecules26247576

• Nasri, Z., Memari, S., Wenske, S., Clemen, R., Martens, U., Delcea, M., Bekeschus, S., Weltmann, K-D., Woedtke, T., Wende, K., "Singlet-Oxygen-Induced Phospholipase A2 Inhibition: A Major Role for Interfacial Tryptophan Dioxidation" (2021), Chemistry - A European Journal, doi: 10.1002/chem.202102306

• Zwicker, P., Geist, N., Göbler, E., Kulke, M., Schmidt, T., Hornschuh, M., Lembke, U., Prinz, C., Delcea, M., Kramer, A., Müller, G., "Improved Adsorption of the Antimicrobial Agent Poly (Hexamethylene) Biguanide on Ti-Al-V Alloys by NaOH Treatment and Impact of Mass Coverage and Contamination on Cytocompatibility" (2021), Coatings, doi: 10.3390/coatings11091118

• Karanth, S., Azinfar, A., Helm, C. A., Delcea, M., "Identification of a critical lipid ratio in raft-like phases exposed to nitric oxide: An AFM study" (2021), Biophysical Journal, doi: 10.1016/j.bpj.2021.06.009

• Janke, U., Mitlehner, A., Weide, A., Gutmann, T., Delcea, M., "Reconstitution of Functional Integrin αIIbβ3 and Its Activation in Plasma Membrane-Mimetic Lipid Environments" (2021), Membranes, doi: 10.3390/membranes11070499

• Kulke M, Nagel F, Schulig L, Geist N, Gabor M, Mayerle J, Lerch MM, Link A, Delcea M. A Hypothesized Mechanism for Chronic Pancreatitis Caused by the N34S Mutation of Serine Protease Inhibitor Kazal-Type 1 Based on Conformational Studies. J Inflamm Res. 2021;14:2111-2119

• Schulig, L., Grabarczyk, P., Geist, N., Delin, M., Forkel, H., Kulke, M., Delcea, M., Schmidt, C. A., Link, A., "Unveiling the N-Terminal Homodimerization of BCL11B by Hybrid Solvent Replica-Exchange Simulations" (2021), International Journal of Molecular Sciences, doi: 10.3390/ijms22073650

• Dharmaraj, K., Dattler, D., Kahlert, H., Lendeckel, U., Nagel, F., Delcea, M., Scholz, F., "The effects of the chemical environment of menaquinones in lipid monolayers on mercury electrodes on the thermodynamics and kinetics of their electrochemistry" (2021), European Biophysics Journal, doi: 10.1007/s00249-021-01512-w

• Clemen, R., Freund, E., Mrochen, D., Miebach, L., Schmidt, A., Rauch, B. H., Lackmann, J-W., Martens, U., Wende, K., Lalk, M., Delcea, M., Bröker, B. M., Bekeschus, S., "Gas Plasma Technology Augments Ovalbumin Immunogenicity and OT-II T Cell Activation Conferring Tumor Protection in Mice" (2021), Advanced Science, doi: 10.1002/advs.202003395

• Buchholz, I., McDonnell, T., Nestler, P., Tharad, S., Kulke, M., Radziszewska, A., Ripoll, V. M., Schmidt, F., Hammer, E., Toca-Herrera, J. L., Rahman, A., Delcea, M., "Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding" (2021), Scientific Reports, doi: 10.1038/s41598-021-84021-2

• Martens, U., Janke, U., Möller, S., Talbot, D., Abou-Hassan, A., Delcea, M., "Interaction of fibrinogen–magnetic nanoparticle bioconjugates with integrin reconstituted into artificial membranes" (2020), Nanoscale, doi: 10.1039/D0NR04181E

• Karanth, S., Meesaragandla, B., Delcea, M., "Changing surface properties of artificial lipid membranes at the interface with biopolymer coated gold nanoparticles under normal and redox conditions" (2020), Biophysical Chemistry, doi: 10.1016/j.bpc.2020.106465

• Meesaragandla, B., Karanth, S., Janke, U., Delcea, M., "Biopolymer-coated gold nanoparticles inhibit human insulin amyloid fibrillation" (2020), Scientific Reports, doi: 10.1038/s41598-020-64010-7

• Palm, G. J., Buchholz, I., Werten, S., Girbardt, B., Berndt, L., Delcea, M., Hinrichs, W., "Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding" (2020), Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, doi: 10.1016/j.bbapap.2020.140404

• Meesaragandla, B., García, I., Biedenweg, D., Toro-Mendoza, J., Coluzza, I., Liz-Marzan, L. M., Delcea, M., "H-bonding-mediated binding and charge reorganization of proteins onto gold nanoparticles" (2020), Phys. Chem. Chem. Phys., doi: 10.1039/C9CP06371D

• Karanth, S., Delcea, M., "Nitrosative stress affects the interaction of integrin alphaIIbbeta3 with its ligands" (2020), Biochimica et Biophysica Acta (BBA) - Biomembranes, doi: 10.1016/j.bbamem.2020.183198

• Lukas, J., Pospech, J., Oppermann, C., Hund, C., Iwanov, K., Pantoom, S., Petters, J., Frech, M., Seemann, S., Thiel, F-G., Modenbach, J-M., Bolsmann, R., Chama, L. d. F., Kraatz, F., El-Hage, F., Gronbach, M., Klein, A., Müller, R., Salloch, S., Weiss, F-U., Simon, P., Wagh, P., Klemenz, A., Krüger, E., Mayerle, J., Delcea, M., Kragl, U., Beller, M., Rolfs, A., Lerch, M. M., Sendler, M., "Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas" (2019), Advances in Medical Sciences, doi: 10.1016/j.advms.2019.03.004

• McDonnell, T., Wincup, C., Buchholz, I., Pericleous, C., Giles, I., Ripoll, V., Cohen, H., Delcea, M., Rahman, A., "The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS" (2019), Blood Reviews, doi: 10.1016/j.blre.2019.100610

• Nguyen, T-H., Xu, Y., Brandt, S., Mandelkow, M., Raschke, R., Strobel, U., Delcea, M., Zhou, W., Liu, J., Greinacher, A., "Characterization of the interaction between platelet factor 4 and homogeneous synthetic low molecular weight heparins" (2019), Journal of Thrombosis and Haemostasis, doi: 10.1111/jth.14657

• Nguyen, T.H., Wesche, J., Raschke, R., Strobel, U., Bui, V.C., Delcea, M., Greinacher, A., "Reactivity of platelet-activating and nonplatelet-activating anti-PF4/heparin antibodies in enzyme immunosorbent assays under different conditions " (2019), J Thromb Haemost, doi: 10.1111/jth.14455

• Buchholz, I., Nagel, F., Klein, A., Wagh, P., Mahajan, U., Greinacher, A., Lerch, M., Mayerle, J., Delcea, M., "The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant" (2019), BBA, doi: 10.1016/j.bbapap.2019.140281

• Kulke, M., Uhrhan, M., Ohler, B., Geist, N., Brüggemann, D., Langel, W., Köppen, S. "Phosphorylation of fibronectin influences the structural stability of the predicted interchain domain" (2019), J. Chem. Inf. Model, doi: 10.1021/acs.jcim.9b00555

• Martens, U., Böttcher, D., Talbot, D., Bornscheuer, U., Abou-Hassan, A., Delcea, M. "Maghemite nanoparticles stabilize the protein corona formed with transferrin presenting different iron-saturation levels" (2019), Nanoscale, 29;11(34):16063-16070, doi: 10.1039/c9nr04967c

• Delcea, M., Helm, CA. “X-ray and Neutron Reflectometry of Thin Films at Liquid Interfaces” (2019), Langmuir, 35: 8519-8530

• Geist, N., Kulke, M., Schulig, L., Link, A., Langel, W. „Replica-Based Protein Structure Sampling Methods II: Advanced Hybrid Solvent TIGER2hs“ (2019), J. Phys. Chem. B, doi.org/10.1021/acs.jpcb.9b03134

• Escobar, A., Muzzio, N., Coy, E., Liu, H., Bindini, E., Andreozzi, P., Wang, GC., Angelome, P., Delcea, M., Grzelczak, M., Moya, SE. “Antibacterial Mesoporous Titania Films with Embedded Gentamicin and Surface Modified with Bone Morphogenetic Protein 2 to Promote Osseointegration in Bone Implants” (2019), Advanced Materials Interfaces, 6: 1801648

• Janke, U., Kulke, M., Buchholz, I., Geist, N., Langel, W., Delcea, M. „Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes” (2019) PLOS ONE, 14: e0214969

• Buchholz, I., Nestler, P., Köppen, S., Delcea, M. "Lysine residues control the conformational dynamics of beta 2-glycoprotein" (2018), Phys Chem Chem Phys, 20: 26819-26829

• Strohbach, A., Pennewitz, M., Glaubitz, M., Palankar. R., Gross, S., Lorenz, F., Materzok, I., Rong, A., Busch, M.C., Felix, S.B., Delcea, M., Busch, R. "The appelin redceptor influences biomechanical and morphological properties of endothelial cells" (2018), J. Cellular Physiology, 233: 6250-6261

• Nguyen, T.H., Medvedev, N., Delcea, M., Greinacher, A. "Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity" (2017), Nature Communications, 8: DOI: 10.1038/ncomms14945

• Dirscherl, C., Palankar, R., Delcea, M., Kolesnikova, T.A., Springer, S. "Specific capture of peptide-receptive major histocompatibility complex class I molecules by antibody micropatterns allows for a novel peptide-binding assay in live cells" (2017), Small, 13: DOI: 10.1002/smll.201602974

• Delcea, M., Greinacher, A. "Biophysical tools to assess the interaction of PF4 with polyanions" (2016), Thrombosis and Haemostasis, 116: 783-791

• Pires, R., Felix, S.B., Delcea, M. "The architecture of neutrophil extracellular traps investigated by atomic force microscopy" (2016), Nanoscale, 8: 14193-14202

• Mahajan, U.M., Teller, S., Sendler, M., Palankar, R., van de Brandt, C., Schwaiger, T., Kühn, J.P., Ribback, S., Glöckl, G., Evert, M., Weitschies, W., Hosten, N., Dombrowski, F., Delcea, M., Weiss, F.U., Lerch, M.M., Mayerle, J. "Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer" (2016), Gut, doi:10.1136/gutjnl-2016-311393

• Nguyen, T.H., Palankar, R., Bui, V.C., Medvedev, N., Greinacher, A. and Delcea, M."Rupture Forces among Human Blood Platelets at different Degrees of Activation" (2016), Scientific Reports, 6: 25402, doi:10.1038/srep25402

• Gregurec, D., Wang, G., Pires, R., Kosutic, M., Lüdtke, T., Delcea, M., and Moya S. "Bioinspired titanium coatings: self-assembly of collagen–alginate films for enhanced osseointegration" (2016), Journal of Material Chemistry B, 4: 1978-1986

• Palankar, R., Glaubitz, M., Martens, U., Medvedev, N., von der Ehe, M., Felix, S.B., Münzenberg, M., and Delcea M. "3D Micropillars Guide the Mechanobiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes" (2016), Advanced Healthcare Materials, 5: 335-341

• Berthold, T., Glaubitz, M., Muschter, S., Gross, S., Palankar, R., Reil, A., Helm, C.A, Bakchoul, T., Schwertz, H., Bux, J., Greinacher, A., and Delcea M. "Human neutrophil antigen-3a antibodies induce neutrophil stiffening and conformational activation of CD11b without shedding of L-selectin" (2015), Transfusion, 55:2939-2948

• Brandt, S., Krauel, K., Jaax, M., Renné, T., Helm, C.A., Hammerschmidt, S., Delcea, M., and Greinacher, A. "Polyphosphates form antigenic complexes with platelet factor 4 (PF4) and enhance PF4-binding to bacteria" (2015), Thrombosis and Haemostasis, 114: 1189-1198

• Greinacher, A., and Delcea, M. "Another surprising finding in heparin-induced thrombocytopenia – eat big" (2015), Journal of Thrombosis and Haemostasis 13 : 1414–1415

• Petkovic, S., Badelt, S., Block, S., Flamm, C., Delcea, M., Hofacker, I., and Müller, S. "Sequence-controlled RNA self-processing: computational design, biochemical analysis and visualization by AFM" (2015), RNA 21:1-12

• Nguyen, T.H., Greinacher, A., and Delcea, M. "Quantitative description of thermodynamic and Kinetic Properties of the platelet factor 4/heparin bonds" (2015), Nanoscale 7: 10130-10139

• Patino, T., Mahajan, U., Palankar, R., Medvedev, N., Walowski, J., Münzenberg, M., Mayerle, J., and Delcea, M. "Multifunctional Gold nanorods for selective plasmonic photothermal therapy in pancreatic cancer cells using ultra-short pulse near-infrared laser irradiation" (2015), Nanoscale, 7: 5328-5337

• Kreimann, M., Brandt, S., Krauel, K., Block, S., Helm, C.A., Weitschies, W., Greinacher, A. and Delcea, M. "Binding of anti-platelet 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4" (2014), Blood 124: 2442-2449.

• Glaubitz, M., Medvedev, N., Pussak, D., Hartmann, L., Schmidt, S., Helm, C.A., and Delcea, M."A novel contact model for AFM indentation experiments on soft spherical cell-like particles" (2014), Soft Matter 10: 6732-6741.

• Medvedev, N., Palankar, R., Krauel, K., Greinacher, A., and Delcea, M. "Micropatterned array to assess the interaction of single platelets with platelet factor 4-heparin-IgG complexes"(2014), Thrombosis and Haemostasis 111, 862-872.

• Castello Serrano, I., Matas Adams, A., Palankar, R., Stoica, G., Palomares, E., and Delcea, M. "Lanthanide-doped nanoparticles for specific recognition of toll-like receptor (TLR) in human neutrophils"(2014), RSC Advances 29, 15040-15047.

• Block, S., Greinacher, A., Helm, C.A., and Delcea, M. "Characterization of bonds formed between platelet factor 4 and negatively charged drugs using single molecule force spectroscopy"(2014), Soft Matter 10, 2775-2784.

• Qiu, Y., Palankar, R., Echeverria, M., Medvedev, N., Moya, S. E., and Delcea, M. "Design of hybrid multimodal poly(lactic-co-glycolic acid) polymer nanoparticles for neutrophil labeling, imaging and tracking"(2013), Nanoscale 5, 12624-12632.

• Palankar, R., Medvedev, N., Rong, A., and Delcea, M. "Fabrication of Quantum Dot Microarrays Using Electron Beam Lithography for Applications in Analyte Sensing and Cellular Dynamics" (2013), ACS Nano 7, 4617-4628.

• Bakchoul T., Zöllner H., Amiral J., Panzer S., Selleng S., Kohlmann T., Brandt S., Delcea M., Warkentin T.E., Sachs U.J. and Greinacher A. "Anti-protamine−heparin antibodies: incidence, clinical relevance and pathogenisis", (2013) Blood 121, 2821-2827.

• Palankar, R., Pinchasik, B.E., Schmidt, S., De Geest, B.G., Fery, A., Möhwald, H., Skirtach, A.G., and Delcea, M., "Mechanical strength and intracellular uptake of CaCO3-templated LbL capsules composed of biodegradable polyelectrolytes: the influence of the number of layers" (2013), Journal of Materials Chemistry B 1: 1175-1181.

• Delcea, M., Sternberg, N., Georgieva, R., Bäumler, H., Möhwald, H., and Skirtach, A. G. "Nanoplasmonics for dual-molecule release through nanopores in the membrane of red blood cells"(2012), ACS Nano 6, 4169-4180.

• Kohler, D., Madaboosi, N., Delcea, M., Schmidt, S., De Geest. B. G., Volodkin, D. V., Möhwald, H., and Skirtach, A. "Patchiness of embedded particles and film stiffness control through concentration of gold nanoparticles"(2012), Adv. Mater. 24, 1095-1100.

• Palivan, C., Onaca, O., Delcea, M., Itel, F., and Meier, W. "Protein-polymer nanoreactors for medical applications" (2012), Chem. Soc. Rev. 41, 2800-2823.

• Delcea, M., Möhwald, H., and Skirtach, A. G. "Stimuli-responsive LbL capsules and nanoshells for drug delivery" (2011), Adv. Drug. Deliv. Rev. 63, 730-747.

• Schmidt, S., Fernandes, P.A.L., De Geest, B.G., Delcea, M., Skirtach, A.G., Möhwald, H., and Fery, A. "Release Properties of Pressurized Microgel Templated Capsules" (2011) Adv. Funct. Mater.  21, 1411-1418.

• Delcea, M., Madaboosi, N., Yashchenok, A. M., Subedi, P., Volodkin, D. V., De Geest, B. G., Möhwald, H., and Skirtach, A. G. "Anisotropic multicompartment micro- and nano-capsules produced via embedding into biocompatible PLL/HA films" (2010), Chem. Comm. 47, 2098-2100.

• Delcea, M., Schmidt, S., Palankar, R., Fernandes, P.A.L., Fery, A., Möhwald, H., and Skirtach, A.G. "Mechanobiology: Correlation Between Mechanical Stability of Microcapsules Studied by AFM and Impact of Cell-Induced Stresses" (2010) Small 6, 2858-2862.

• Yashchenok, A.M., Delcea, M., Videnova, K., Jares-Erijman, E.A., Jovin, T.M., Konrad, M., Möhwald, H., and Skirtach, A.G. "Enzyme Reaction in the Pores of CaCO3 Particles upon Ultrasound Disruption of Attached Substrate-Filled Liposomes" (2010) Angewandte Chemie Int. Ed. 49, 8116-8120.

• Delcea, M., Yashchenok, A.M., Videnova, K., Kreft, O., Möhwald, H., and Skirtach, A.G. "Multicompartmental Micro- and Nanocapsules: Hierarchy and Applications in Biosciences" (2010) Macromolecular Bioscience 10: 465-474 (Invited Feature Article).

• Fernandes, P.A.L., Delcea, M., Skirtach, A.G., Möhwald, H., and Fery, A. "Quantification of release from microcapsules upon mechanical deformation with AFM" (2010) Soft Matter 6: 1879-1883.

• Volodkin, D.V., Delcea, M., Möhwald, H., and Skirtach, A.G. "Remote Near-IR Light Activation of a Hyaluronic Acid/Poly(L-lysine) Multilayered Film and Film-Entrapped Microcapsules" (2009) ACS Applied Materials & Interfaces 1: 1705-1710.

• Delcea, M., Krastev, R., Gutlebert, T., Pum, D., Sleytr, U.B., and Toca-Herrera, J.L. "Thermal stability, mechanical properties and water content of bacterial protein layers recrystallized on polyelectrolyte multilayers" (2008) Soft Matter 4: 1414-1421.

• Delcea, M., Krastev, R., Gutlebert, T., Pum, D., Sleytr, U.B., and Toca-Herrera, J.L. "Mapping bacterial surface layers affinity to polyelectrolytes through the building of hybrid macromolecular structures" (2007) Journal of Nanoscience and Nanotechnology 7: 4260-4266.

_{aktualisiert am 02.03.2023 durch
N. Geist}